SRI international provides a continuing resource for conducting the following types of studies with agents selected for preclinical development through the programs listed above: (1) development of sensitive analytical methods to quantify compounds in plasma, urine, tissues, and other biological matrices;(2) plasma stability and protein binding studies, which are conducted at an early stage of compound development to ensure proper sample handling and to aid in the interpretation of in vivo studies;(3) pharmacokinetic evaluation of test compounds following administration to animals by various routes and schedules, including a determination of bioavailability by various routes;(4) quantification and identification of drug metabolites generated in vivo and in various in vitro systems (S9 fractions, microsomes, hepatocytes, P450 isoforms, liver slices);and (5) correlation of compound effects on putative molecular targets (pharmacodynamic effects) with compound exposures.

Agency
National Institute of Health (NIH)
Type
Research and Development Contracts (N01)
Project #
261201100012C-4-0-2
Application #
8602503
Study Section
Project Start
2011-07-01
Project End
2016-06-30
Budget Start
Budget End
Support Year
Fiscal Year
2013
Total Cost
$27,669
Indirect Cost
Name
Sri International
Department
Type
DUNS #
009232752
City
Menlo Park
State
CA
Country
United States
Zip Code
94025