The overall objective of this task order is to evaluate two selective estrogen receptor (ER) agonists, Prinaberel (ERB-041) and LY500307, in inhibition of androgen-dependent prostate carcinogenesis induced in the Wistar-Unilever rat by N-methy-N-nitrosourea (MNU) plus testosterone. Furthermore, this task order also requires studying the chemopreventive efficacy of these two agents in association with specific signaling pathway(s) involved in cell proliferation, differentiation, and apoptosis in prostate.

Agency
National Institute of Health (NIH)
Type
Research and Development Contracts (N01)
Project #
261201200016I-0-26100003-1
Application #
8739519
Study Section
Project Start
2013-09-18
Project End
2015-09-17
Budget Start
Budget End
Support Year
Fiscal Year
2013
Total Cost
$686,259
Indirect Cost
Name
Iit Research Institute
Department
Type
DUNS #
005447826
City
Chicago
State
IL
Country
United States
Zip Code
60616