For the past two decades RNA interference based technologies have offered an attractive potential approach for treating a variety of cancers where an 'oncogene'has been implicated in tumorigenesis. The current challenge to realizing the theoretical potential of siRNA efficacy is successful delivery. Head and neck squamous cell carcinomas (H&NSCC) are caused by tobacco and alcohol use, but recently an increasing percentage is recognized to be caused by HPV. E7 is the dominant HPV oncoprotein that is responsible for head and neck cancer which has a very poor prognosis. Although advances in surgery, radiation and conventional chemotherapy strategies for HNSCC are gradually improving outcomes, there is a clear unmet medical need for novel agents that can target the E7 oncogene.

Agency
National Institute of Health (NIH)
Type
Research and Development Contracts (N01)
Project #
261201300077C-0-0-1
Application #
8762802
Study Section
Project Start
2013-09-25
Project End
2014-06-24
Budget Start
Budget End
Support Year
Fiscal Year
2013
Total Cost
$198,141
Indirect Cost
Name
Aura Biosciences, Inc.
Department
Type
DUNS #
829642474
City
Cambridge
State
MA
Country
United States
Zip Code
02140