Genome-wide association studies have identified common genetic variants associated with common cancers, including colorectal cancer, breast cancer, prostate cancer, lung cancer and esophageal cancer. These variants can be combined to create polygenic models, through which the additive effects of genes, along with environmental determinants, create a normal distribution of disease risk in the population. Polygenic models and polygenic inheritance lead to low individual risk prediction. However, it is unclear if polygenic models could be useful as risk stratifiers in population screening to target population subgroups at high risk and reduce screening in population subgroups at low risk.

Agency
National Institute of Health (NIH)
Type
Resource and Support Contracts (N02)
Project #
261201300331P-0-0-1
Application #
8761165
Study Section
Project Start
2013-09-04
Project End
Budget Start
Budget End
Support Year
Fiscal Year
2013
Total Cost
$127,257
Indirect Cost
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322