A goal of the National Institute on Alcohol Abuse and Alcoholism (NIAAA), in its efforts to reduce alcohol-related problems, is to understand long-term outcomes of patients who have received treatment for alcohol dependence as well as identify factors that affect these outcomes. Most studies to date have provided only short-to medium term patient follow-up (usually one year or less). It is now well-recognized that alcohol dependence is frequently a long-term chronic condition. Yet the longer term effects of treatment, factors affecting longer-term treatment outcomes and methods of evaluating these outcomes are not well studied or understood. The current project addresses this gap in knowledge in an efficient and cost-effective manner through long term follow-up of subjects enrolled in NIAAA sponsored randomized clinical trials (RCT). The contract builds on previously and currently funded studies of well-characterized RCT treatment populations. RCT medications to date include naltrexone and acamprosate, from the "Combining Medications and Behavioral Interventions" (COMBINE) study;and quetiapine and keppra, medications which are part of an Institute-directed set of Phase II clinical trials under the NIAAA Clinical Investigations Group (NCIG).

Agency
National Institute of Health (NIH)
Type
Research and Development Contracts (N01)
Project #
267200800021C-8-0-1
Application #
8742493
Study Section
Project Start
2008-09-25
Project End
2014-01-31
Budget Start
Budget End
Support Year
Fiscal Year
2013
Total Cost
$59,963
Indirect Cost
Name
Research Triangle Institute
Department
Type
DUNS #
004868105
City
Research Triangle
State
NC
Country
United States
Zip Code
27709