The Population Genetics Analysis program is focused on human genetic variation underlying differential immune responses to vaccination against or infection by human pathogens. The goals are to replicate previously identified human genotype-phenotype associations and elucidate the functional relevance of the validated genetic variants that correlate with immune outcome. Research will focus on one or more of the emerging or re-emerging Group I, II, or III infectious agents listed at http://www3.niaid.nih.gov/topics/emerging/list.htm. This information will help to identify individual risk factors, will expand our understanding of immune mechanisms applicable to a broad range of human diseases, and will help define biomarkers of risk and immunity that might lead to novel diagnostic tests of infection or vaccine response. This particular contract will perform clinical research on human samples from populations in West Africa and examine host genetic factors in resistance to lassa hemorrhagic fever.

Agency
National Institute of Health (NIH)
Type
Research and Development Contracts (N01)
Project #
272201000022C-4-0-1
Application #
8602410
Study Section
Project Start
2010-09-30
Project End
2013-12-31
Budget Start
Budget End
Support Year
Fiscal Year
2013
Total Cost
$1,967,459
Indirect Cost
Name
Broad Institute, Inc.
Department
Type
DUNS #
623544785
City
Cambridge
State
MA
Country
United States
Zip Code
02142