The Population Genetics Analysis program is focused on human genetic variation underlying differential immune responses to vaccination against or infection by human pathogens. The goals are to replicate previously identified human genotype-phenotype associations and elucidate the functional relevance of the validated genetic variants that correlate with immune outcome. Research will focus on one or more of the emerging or re-emerging Group I, II, or III infectious agents listed at http://www3.niaid.nih.gov/topics/emerging/list.htm. This information will help to identify individual risk factors, will expand our understanding of immune mechanisms applicable to a broad range of human diseases, and will help define biomarkers of risk and immunity that might lead to novel diagnostic tests of infection or vaccine response. This contract will study the genetic variants associated with smallpox vaccine immune response heterogeneity

Agency
National Institute of Health (NIH)
Type
Research and Development Contracts (N01)
Project #
272201000025C-3-0-1
Application #
8751441
Study Section
Project Start
2010-09-30
Project End
2014-09-29
Budget Start
Budget End
Support Year
Fiscal Year
2013
Total Cost
$1,996,839
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905