The NIH Tetramer Facility provides custom synthesis and distribution of soluble major histocompatibility complex (MHC)-peptide tetramer reagents that can be used to detect antigen-specific T cells. These reagents include custom class I tetramers for mouse, non-human primate, and human alleles;class II reagents for mouse, non-human primate and human alleles;mouse and human CD1d tetramers;and human CD1a-c tetramers. The NIH Tetramer Facility also is developing novel technologies to improve production and expand the range of available MHC and CD1 tetramers. The tetramer reagents can be applied to studies ranging from basic immunology and protection against microbial pathogens to control of immune-mediated diseases and tumor metastases.

Agency
National Institute of Health (NIH)
Type
Research and Development Contracts (N01)
Project #
272201300006C-1-0-3
Application #
8751808
Study Section
Project Start
2013-03-21
Project End
2018-03-20
Budget Start
Budget End
Support Year
Fiscal Year
2013
Total Cost
$1,000,000
Indirect Cost
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322