The University of Southwestern Louisiana New Iberia Research Center (USL-NIRC) currently maintains 246 chimpanzees (Pan troglodytes) through support by the National Institute of Neurological Diseases and Strokes and the National Center for Research Resources. A five year moratorium on breeding imposed by the National Center for Research Resources in 1997 has effectively reduced current operating costs and has minimized the immediate strain of adding additional animals into the systems. Consistent with the moratorium, USL-NIRC has minimized the birth rate without disrupting family groups or permanently altering male or female animals assigned to the program by applying levonorgestrel implants in breeding age females. There still remains, however, a serious problem in regards to adequate space to accommodate animals which have been produced in the last 10 to 12 years. A large population of animals between the ages of 1 and 12 years are currently being housed in family groups and as peer groups. As these animals approach maturity and beyond it will be imperative that additional space is provided to maintain a health and available population of chimpanzees for access by biomedical and behavioral research communities. We are proposing to renovate approximately 10,000 square feet of existing facilities at the USL-NIRC into large indoor/outdoor holding cages with the specific aim of accommodating maturing animals which have been born into the system. In addition we propose that long term strategies include relocating animals from other facilities, therefore consolidating the national efforts to maintain chimpanzees for ready use by the biomedical and behavioral research communities.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Facilities Construction Grant (C06)
Project #
1C06RR014491-01
Application #
6039181
Study Section
Scientific and Technical Review Board on Biomedical and Behavioral Research Facilities (STRB)
Program Officer
Mccullough, Willie
Project Start
1999-09-30
Project End
2003-09-29
Budget Start
1999-09-30
Budget End
2003-09-29
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Louisiana at Lafayette
Department
Type
Other Domestic Higher Education
DUNS #
City
Lafayette
State
LA
Country
United States
Zip Code
70503
Zhou, Xiang; Cain, Carolyn E; Myrthil, Marsha et al. (2014) Epigenetic modifications are associated with inter-species gene expression variation in primates. Genome Biol 15:547
Reno, Philip L; McLean, Cory Y; Hines, Jasmine E et al. (2013) A penile spine/vibrissa enhancer sequence is missing in modern and extinct humans but is retained in multiple primates with penile spines and sensory vibrissae. PLoS One 8:e84258
McIntosh, Annick M; Bennett, Calvin; Dickson, Dara et al. (2012) The apolipoprotein E (APOE) gene appears functionally monomorphic in chimpanzees (Pan troglodytes). PLoS One 7:e47760
Cain, Carolyn E; Blekhman, Ran; Marioni, John C et al. (2011) Gene expression differences among primates are associated with changes in a histone epigenetic modification. Genetics 187:1225-34
Callendret, BenoƮt; Bukh, Jens; Eccleston, Heather B et al. (2011) Transmission of clonal hepatitis C virus genomes reveals the dominant but transitory role of CD8? T cells in early viral evolution. J Virol 85:11833-45
Perry, George H; Marioni, John C; Melsted, Pall et al. (2010) Genomic-scale capture and sequencing of endogenous DNA from feces. Mol Ecol 19:5332-44
Fontenot, M B; Musso, M W; Watson, S L et al. (2010) Characterization of cerebrospinal fluid monoamine metabolites in peripubertal chimpanzees (Pan troglodytes). J Med Primatol 39:24-31
Anestis, Stephanie F; Breakey, Alicia A; Beuerlein, Melanie M et al. (2009) Specific gravity as an alternative to creatinine for estimating urine concentration in captive and wild chimpanzee (Pan troglodytes) Samples. Am J Primatol 71:130-5
Bowen, David G; Shoukry, Naglaa H; Grakoui, Arash et al. (2008) Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection. J Virol 82:5109-14
Perry, George H; Yang, Fengtang; Marques-Bonet, Tomas et al. (2008) Copy number variation and evolution in humans and chimpanzees. Genome Res 18:1698-710

Showing the most recent 10 out of 11 publications