This proposal is for years 21-25 of the Harvard AITRP, which proposes strong HIV/AIDS research training for applicants from 6 developing countries: Botswana, China, Nigeria, Senegal, Tanzania, and Thailand. The training is linked to specific sites and collaborators in these countries where active research collaborations are well established. Most of the faculty are associated with the Harvard School of Public Health (HSPH), which has extensive experience training students from developing countries. The research training is multidisciplinary, and linked to problems of prevention and treatment, including design of clinical trials, surveillance, mother-to-child transmission and chemoprophylaxis, vaccine design, drug efficacy and toxicity, drug resistance, behavioral issues, and HIV/AIDS health policy and cost effectiveness. The educational focus is on pre- and postdoctoral training in AIDS research, as well as shorter-term training in both Boston and the foreign sites. In the latter case, selected earlier AITRP trainees will be involved in south-to-south training in the developing country sites. The large number of foreign health professionals who have trained at HSPH serve, along with developing country collaborators, as a network for applicant referrals. The faculty advisors for the program have expertise in epidemiology (9), infectious diseases (7), immunology or virology (7), behavioral sciences (5), biostatistics (3), ethics (1), and international policy and economics (3). Most faculty members listed have active collaborations in one or more of the developing countries cited as partner countries, and have mentored trainees in the past. Numerous AIDS related courses, seminars, and workshops are available for trainees. Each trainee will have a principal advisor and a faculty advisory committee. Selection of trainees under a selection committee is based on previous academic performance, references, experience, and assurance that the candidates will return to participate in AIDS research in a developing country. The quality of the program will be monitored by a Training Advisory Group composed of experts from the US and from developing countries.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW000004-25
Application #
8262692
Study Section
Special Emphasis Panel (ZRG1-BDA-K (50))
Program Officer
Mcdermott, Jeanne
Project Start
1993-09-21
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2014-05-31
Support Year
25
Fiscal Year
2012
Total Cost
$742,901
Indirect Cost
$49,344
Name
Harvard University
Department
Microbiology/Immun/Virology
Type
Schools of Public Health
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115
Powis, Kathleen M; Smeaton, Laura; Hughes, Michael D et al. (2016) In-utero triple antiretroviral exposure associated with decreased growth among HIV-exposed uninfected infants in Botswana. AIDS 30:211-20
Mwiru, Ramadhani S; Spiegelman, Donna; Duggan, Christopher et al. (2015) Nutritional Status and Other Baseline Predictors of Mortality among HIV-Infected Children Initiating Antiretroviral Therapy in Tanzania. J Int Assoc Provid AIDS Care 14:172-9
Novitsky, Vlad; Bussmann, Hermann; Okui, Lillian et al. (2015) Estimated age and gender profile of individuals missed by a home-based HIV testing and counselling campaign in a Botswana community. J Int AIDS Soc 18:19918
Novitsky, Vlad; Kühnert, Denise; Moyo, Sikhulile et al. (2015) Phylodynamic analysis of HIV sub-epidemics in Mochudi, Botswana. Epidemics 13:44-55
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Mwiru, Ramadhani S; Spiegelman, Donna; Duggan, Christopher et al. (2014) Growth among HIV-infected children receiving antiretroviral therapy in Dar es Salaam, Tanzania. J Trop Pediatr 60:179-88
Powis, Kathleen; Lockman, Shahin; Smeaton, Laura et al. (2014) Vitamin D insufficiency in HIV-infected pregnant women receiving antiretroviral therapy is not associated with morbidity, mortality or growth impairment in their uninfected infants in Botswana. Pediatr Infect Dis J 33:1141-7
Khavari, Nasim; Jiang, Hongyu; Manji, Karim et al. (2014) Maternal multivitamin supplementation reduces the risk of diarrhoea among HIV-exposed children through age 5 years. Int Health 6:298-305
McDonald, Bethan; Moyo, Sikhulile; Gabaitiri, Lesego et al. (2013) Persistently elevated serum interleukin-6 predicts mortality among adults receiving combination antiretroviral therapy in Botswana: results from a clinical trial. AIDS Res Hum Retroviruses 29:993-9
Novitsky, Vlad; Wang, Rui; Rossenkhan, Raabya et al. (2013) Intra-host evolutionary rates in HIV-1C env and gag during primary infection. Infect Genet Evol 19:361-8

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