This is the Baylor College of Medicine's re-competing research training application for funding under Program Announcement PAR-10-219, AIDS International Training and Research Program (AITRP). The Baylor College of Medicine International Pediatric AIDS Initiative (BIPAI) at Texas Children's Hospital was established in 1996 with a goal of improving the health and lives of HIV-infected children and families globally through expanded access to HIV/AIDS care and treatment, health professional education and training and clinical research. BIPAI seeks through its AITRP to develop collaborative international research training activities that will enhance sustainable research capacity in partner countries hard hit by HIV/AIDS. The ultimate goal of our activities is to inform the prevention, care and treatment of HIV-infected children and families, thereby improving health and lives and catalyzing expanded access to health-restoring and life-prolonging care and treatment. The primary focus is operational research related to the care and treatment of pediatric HIV/AIDS. This application requests support for the renewal, enhancement, and expansion of our AITRP. We are requesting funding for a total of six long-term trainees at any given time. This increase in research training capacity will be critical to fulfilling our commitments to partner institutions and governments for capacity building activities. It is difficult to overstate the catalytic role that AITRP funding has had in BIPAI's development over the past ten years. Baylor's AITRP serves an absolutely essential role in building the research capacity that will help to sustain the BIPAI Children's Clinical Centers of Excellence Network over time. The past five years in particular have been characterized by a blossoming of the research enterprise within the BIPAI Network, providing a rich training environment for current and future AITRP scholars. The challenge and opportunity exist now to harness these phenomenal resources to scale up and inform the prevention, care and treatment of hundreds of thousands of HIV- infected children, impacting millions of young lives across the globe.

Public Health Relevance

This is the Baylor College of Medicine's re-competing research training application for funding under Program Announcement PAR-10-219, AIDS International Training and Research Program (AITRP). BIPAI seeks through its AITRP to develop collaborative international research training activities that will enhance sustainable research capacity in partner countries hard hit by HIV/AIDS. The ultimate goal of our activities is to inform the prevention, care and treatment of HIV-infected children and families, thereby improving health and lives and catalyzing expanded access to health-restoring and life-prolonging care and treatment.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW001036-13
Application #
8464821
Study Section
Special Emphasis Panel (ZRG1-BDA-N (51))
Program Officer
Mcdermott, Jeanne
Project Start
2000-09-30
Project End
2016-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
13
Fiscal Year
2013
Total Cost
$480,452
Indirect Cost
$31,482
Name
Baylor College of Medicine
Department
Pediatrics
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Couturier, Jacob; Hutchison, Alexander T; Medina, Miguel A et al. (2014) HIV replication in conjunction with granzyme B production by CCR5+ memory CD4 T cells: Implications for bystander cell and tissue pathologies. Virology 462-463:175-88
Kirk, Brianna L; Gomila, Andres; Matshaba, Mogomotsi et al. (2013) Early outcomes of darunavir- and/or raltegravir-based antiretroviral therapy in children with multidrug-resistant HIV at a pediatric center in Botswana. J Int Assoc Provid AIDS Care 12:90-4
Buck, W C; Olson, D; Kabue, M M et al. (2013) Risk factors for mortality in Malawian children with human immunodeficiency virus and tuberculosis co-infection. Int J Tuberc Lung Dis 17:1389-95
Gingaras, Cosmina; Danielson, Bryan P; Vigil, Karen J et al. (2012) Absence of XMRV in peripheral blood mononuclear cells of ARV-treatment naive HIV-1 infected and HIV-1/HCV coinfected individuals and blood donors. PLoS One 7:e31398
Tukei, Vincent J; Kekitiinwa, Adeodata; Beasley, R Palmer (2011) Prevalence and outcome of HIV-associated malignancies among children. AIDS 25:1789-93
Braun, Maureen; Kabue, Mark M; McCollum, Eric D et al. (2011) Inadequate coordination of maternal and infant HIV services detrimentally affects early infant diagnosis outcomes in Lilongwe, Malawi. J Acquir Immune Defic Syndr 56:e122-8
Buck, W Chris; Kabue, Mark M; Kazembe, Peter N et al. (2010) Discontinuation of standard first-line antiretroviral therapy in a cohort of 1434 Malawian children. J Int AIDS Soc 13:31
Kamiru, H N; Ross, M W; Bartholomew, L K et al. (2009) Effectiveness of a training program to increase the capacity of health care providers to provide HIV/AIDS care and treatment in Swaziland. AIDS Care 21:1463-70
Kline, Mark W; Ferris, Margaret G; Jones, David C et al. (2009) The Pediatric AIDS Corps: responding to the African HIV/AIDS health professional resource crisis. Pediatrics 123:134-6
Villasenor-Sierra, Alberto; Lomas-Bautista, Maricarmen; Aguilar-Benavides, Sergio et al. (2008) Serotypes and susceptibility of Streptococcus pneumoniae strains isolated from children in Mexico. Salud Publica Mex 50:330-3

Showing the most recent 10 out of 23 publications