This is the second competitive renewal application for the UNC AIDS International Training and Research Program. We propose to continue to provide training in three countries: The Peoples Republic of China, Malawi and Cameroon. Investigators at UNC have worked in China since 1979, Malawi since 1989, and Cameroon since 1998. The UNC AITRP has embraced several guiding principles. First, we use training to build strong ties to key in-country organizations. Trainees with guaranteed """"""""return jobs"""""""" in these organizations are preferentially selected. Second, our training opportunities build on funded research projects and bridge many of the strengths of UNC. Wherever possible we combine basic, clinical and epidemiological training and research in order to build critical mass. Third, we have used the Fogarty training to promote international research, working with many collaborators and funding agencies. Fourth, we have developed south-to-south and international collaborations to facilitate training and ongoing research opportunities. For example, University of the Witwatersrand is a training site for Malawi personnel, and we have developed a strong collaboration with the London School of Hygiene and Tropical Medicine for training of physicians from Malawi (a former British protectorate). Fifth, we have looked for opportunities for evolution and innovation. Such efforts have been particularly important in the development of a new Department of Public Health at the Malawi College of Medicine (which has received dedicated Fogarty support), extensive research ethics and IRB training in China, and rapid technology transfer in all three UNC AITRP countries. Sixth, we are committed to in- country leadership and ongoing mentorship after the trainee has completed our program.

Public Health Relevance

Fogarty trainees are serving in key leadership positions and are in the center of exciting and critical research activities. Working with our collaborating institutions we have assessed the priority health needs of our partner countries and propose a research training program that addresses the countries'research needs as well as the developmental plans of our collaborating institutions.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW001039-15
Application #
8458091
Study Section
Special Emphasis Panel (ZRG1-BDA-K (51))
Program Officer
Mcdermott, Jeanne
Project Start
1998-09-30
Project End
2014-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
15
Fiscal Year
2013
Total Cost
$564,729
Indirect Cost
$38,682
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Davis, Nicole L; Miller, William C; Hudgens, Michael G et al. (2016) Maternal and Breastmilk Viral Load: Impacts of Adherence on Peripartum HIV Infections Averted-The Breastfeeding, Antiretrovirals, and Nutrition Study. J Acquir Immune Defic Syndr 73:572-580
Hampel, Daniela; Shahab-Ferdows, Setareh; Adair, Linda S et al. (2016) Thiamin and Riboflavin in Human Milk: Effects of Lipid-Based Nutrient Supplementation and Stage of Lactation on Vitamer Secretion and Contributions to Total Vitamin Content. PLoS One 11:e0149479
Davis, Nicole L; Miller, William C; Hudgens, Michael G et al. (2016) Maternal and Breast Milk Viral Load: Impacts of Adherence on Peri-Partum HIV Infections Averted - the BAN Study. J Acquir Immune Defic Syndr :
Manga, Simon; Parham, Groesbeck; Benjamin, Nkoum et al. (2015) Cervical Cancer Screening in Cameroon: Interobserver Agreement on the Interpretation of Digital Cervicography Results. J Low Genit Tract Dis 19:288-94
Nelson, Julie A E; Fokar, Ali; Hudgens, Michael G et al. (2015) Frequent nevirapine resistance in infants infected by HIV-1 via breastfeeding while on nevirapine prophylaxis. AIDS 29:2131-8
Chang, Tiffany S; Wiener, Jeffrey; Dollard, Sheila C et al. (2015) Effect of cytomegalovirus infection on breastfeeding transmission of HIV and on the health of infants born to HIV-infected mothers. AIDS 29:831-6
Sanders, Eduard J; Wahome, Elizabeth; Powers, Kimberly A et al. (2015) Targeted screening of at-risk adults for acute HIV-1 infection in sub-Saharan Africa. AIDS 29 Suppl 3:S221-30
Davis, Nicole L; Barnett, Eric J; Miller, William C et al. (2015) Impact of daily cotrimoxazole on clinical malaria and asymptomatic parasitemias in HIV-exposed, uninfected infants. Clin Infect Dis 61:368-74
Kourtis, Athena P; Wiener, Jeffrey; Chang, Tiffany S et al. (2015) Cytomegalovirus IgG Level and Avidity in Breastfeeding Infants of HIV-Infected Mothers in Malawi. Clin Vaccine Immunol 22:1222-6
Ramlal, Roshan T; Tembo, Martin; King, Caroline C et al. (2015) Dietary patterns and maternal anthropometry in HIV-infected, pregnant Malawian women. Nutrients 7:584-94

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