This is the second competitive renewal application for the UNC AIDS International Training and Research Program. We propose to continue to provide training in three countries: The Peoples Republic of China, Malawi and Cameroon. Investigators at UNC have worked in China since 1979, Malawi since 1989, and Cameroon since 1998. The UNC AITRP has embraced several guiding principles. First, we use training to build strong ties to key in-country organizations. Trainees with guaranteed "return jobs" in these organizations are preferentially selected. Second, our training opportunities build on funded research projects and bridge many of the strengths of UNC. Wherever possible we combine basic, clinical and epidemiological training and research in order to build critical mass. Third, we have used the Fogarty training to promote international research, working with many collaborators and funding agencies. Fourth, we have developed south-to-south and international collaborations to facilitate training and ongoing research opportunities. For example, University of the Witwatersrand is a training site for Malawi personnel, and we have developed a strong collaboration with the London School of Hygiene and Tropical Medicine for training of physicians from Malawi (a former British protectorate). Fifth, we have looked for opportunities for evolution and innovation. Such efforts have been particularly important in the development of a new Department of Public Health at the Malawi College of Medicine (which has received dedicated Fogarty support), extensive research ethics and IRB training in China, and rapid technology transfer in all three UNC AITRP countries. Sixth, we are committed to in- country leadership and ongoing mentorship after the trainee has completed our program.

Public Health Relevance

Fogarty trainees are serving in key leadership positions and are in the center of exciting and critical research activities. Working with our collaborating institutions we have assessed the priority health needs of our partner countries and propose a research training program that addresses the countries'research needs as well as the developmental plans of our collaborating institutions.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW001039-15
Application #
8458091
Study Section
Special Emphasis Panel (ZRG1-BDA-K (51))
Program Officer
Mcdermott, Jeanne
Project Start
1998-09-30
Project End
2014-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
15
Fiscal Year
2013
Total Cost
$564,729
Indirect Cost
$38,682
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Sellers, Christopher J; Lee, Hana; Chasela, Charles et al. (2015) Reducing lost to follow-up in a large clinical trial of prevention of mother-to-child transmission of HIV: the Breastfeeding, Antiretrovirals and Nutrition study experience. Clin Trials 12:156-65
Flax, Valerie L; Bentley, Margaret E; Combs Jr, Gerald F et al. (2014) Plasma and breast-milk selenium in HIV-infected Malawian mothers are positively associated with infant selenium status but are not associated with maternal supplementation: results of the Breastfeeding, Antiretrovirals, and Nutrition study. Am J Clin Nutr 99:950-6
Jarvis, Joseph N; Bicanic, Tihana; Loyse, Angela et al. (2014) Determinants of mortality in a combined cohort of 501 patients with HIV-associated Cryptococcal meningitis: implications for improving outcomes. Clin Infect Dis 58:736-45
Chasela, Charles S; Kourtis, Athena P; Wall, Patrick et al. (2014) Hepatitis B virus infection among HIV-infected pregnant women in Malawi and transmission to infants. J Hepatol 60:508-14
Henderson, Gail; Maman, Suzanne; Huang, Yingying et al. (2014) Social contexts of heterosexual transmission of HIV/STI in Liuzhou City, China. AIDS Behav 18 Suppl 2:S111-7
Widen, Elizabeth M; Bentley, Margaret E; Kayira, Dumbani et al. (2014) Changes in soluble transferrin receptor and hemoglobin concentrations in Malawian mothers are associated with those values in their exclusively breastfed, HIV-exposed infants. J Nutr 144:367-74
Henley, Catherine; Forgwei, Gideon; Welty, Thomas et al. (2013) Scale-up and case-finding effectiveness of an HIV partner services program in Cameroon: an innovative HIV prevention intervention for developing countries. Sex Transm Dis 40:909-14
Parker, Megan E; Tembo, Martin; Adair, Linda et al. (2013) The health of HIV-exposed children after early weaning. Matern Child Nutr 9:217-32
Kourtis, Athena P; Wiener, Jeffrey; Kayira, Dumbani et al. (2013) Health outcomes of HIV-exposed uninfected African infants. AIDS 27:749-59
McLaughlin, Megan M; Chow, Eric P F; Wang, Cheng et al. (2013) Sexually transmitted infections among heterosexual male clients of female sex workers in China: a systematic review and meta-analysis. PLoS One 8:e71394

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