Malaria is the most fatal vector-borne disease in sub-Saharan Africa. Insecticide-treated nets, indoor residual spray and artemisinin-based combination therapy are the primary intervention tools. However, the evolution and spread of insecticide resistance and drug resistance hinder the efficacy of these tools. Developing new tools for vector control and for resistance monitoring and management is of paramount importance. Recent advancements in ecology, molecular biology, and genomics provide exciting opportunities for developing new malaria vector control and resistance-monitoring tools. However, the vast majority of scientists from malaria-endemic countries have not been able to use these new technologies in their research. The scientific objectives of this competing renewal training application focus on population regulation of African malaria vectors, development of new malaria vector surveillance and control tools, and population genetics and antimalarial drug-resistance in malaria parasites. The overarching goal of this program is to enhance malaria research capacity and advance the career development of promising young scientists from sub-Saharan African countries. We propose to accomplish this goal by training four postdoctoral fellows, five Ph.D. students and five junior scientists. In addition to obtaining research experience in both laboratory-based molecular biology and field-based ecological research, each year, all trainees will attend a core training curriculum that focuses on biostatistics and data management, molecular population genetics, population ecology, scientific writing and responsible conduct of research. The superb infrastructure and capacity in the international training sites (ICIPE and KEMRI in Kenya) and in the US (University of California at Irvine and UC-Riverside) are particularly suitable for the proposed training. This training program will contribute significantly to the career development of African scientists by bridging laboratory and field research experience in vector and parasite biology, by equipping them with new technologies, by providing opportunities for them to develop valuable Africa-wide and international linkages, and by enabling them to develop independent or collaborative research projects.

Public Health Relevance

This research will enhance our understanding of the fundamental biology of mosquito vectors and malaria parasites, and will facilitate the development of new malaria vector surveillance and control tools. The program will advance the careers of scientists from malaria endemic African countries and enhance the research capacity in Africa by transferring state-of-the-art technology to African scientists.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW001505-12
Application #
8109993
Study Section
Special Emphasis Panel (ZRG1-ICP2-B (50))
Program Officer
Sina, Barbara J
Project Start
2000-09-29
Project End
2015-05-31
Budget Start
2011-06-01
Budget End
2012-05-31
Support Year
12
Fiscal Year
2011
Total Cost
$198,720
Indirect Cost
Name
University of California Irvine
Department
Type
Schools of Public Health
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
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Kapesa, Anthony; Kweka, Eliningaya J; Atieli, Harrysone et al. (2017) Why some sites are responding better to anti-malarial interventions? A case study from western Kenya. Malar J 16:498
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Zhou, Guofa; Wiseman, Virginia; Atieli, Harrysone E et al. (2016) The impact of long-lasting microbial larvicides in reducing malaria transmission and clinical malaria incidence: study protocol for a cluster randomized controlled trial. Trials 17:423
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Zhou, Guofa; Lee, Ming-Chieh; Githeko, Andrew K et al. (2016) Insecticide-Treated Net Campaign and Malaria Transmission in Western Kenya: 2003-2015. Front Public Health 4:153
Dixit, Amruta; Lee, Ming-Chieh; Goettsch, Brittany et al. (2016) Discovering the cost of care: consumer, provider, and retailer surveys shed light on the determinants of malaria health-seeking behaviours. Malar J 15:179
Zhou, Guofa; Yewhalaw, Delenasaw; Lo, Eugenia et al. (2016) Analysis of asymptomatic and clinical malaria in urban and suburban settings of southwestern Ethiopia in the context of sustaining malaria control and approaching elimination. Malar J 15:250
Ototo, Ednah N; Mbugi, Jenard P; Wanjala, Christine L et al. (2015) Surveillance of malaria vector population density and biting behaviour in western Kenya. Malar J 14:244

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