Pregnant women and children are the groups most susceptible to malaria, which directly kills 1 million children each year. Pregnancy malaria accounts for a large proportion of low birth weight deliveries in endemic areas, and therefore indirectly contributes to an untold number of additional deaths during infancy. Our broad objective is to establish a center of excellence in Tanzania to focus on malaria of pregnant women and children, with an emphasis on research and intervention. This proposal is submitted in conjunction with an application for a Global Network Research Unit Award that will support studies of malaria at the mother-child interface.
Our specific aims i n this proposal will be: 1) establish the technical base within Tanzania to support maternal and early childhood biomedical research;2) provide training at the medical technologist, MSc, PhD, and postdoctoral levels in tropical health and maternal/child health;3) institute a yearly workshop for students, scientists and clinicians from the East African region that will focus on malaria in pregnant women and children, with an emphasis on drug treatment, research ethics, and recent scientific advances. We intend to develop facilities and scientific expertise within the Tanzanian center that will allow future collaborative research on maternal and child health issues, both regional and international. We anticipate that this center will become an important regional asset for scientific networking, formulation of public health policy regarding prophylaxis and treatment of women and children, and a site for interventional studies, including research into behavioral measures (eg, breastfeeding) and vaccines that may reduce malaria morbidity and mortality in these vulnerable populations.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW005509-11
Application #
8462010
Study Section
Special Emphasis Panel (ZRG1-ICP2-B (51))
Program Officer
Sina, Barbara J
Project Start
2001-12-14
Project End
2014-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
11
Fiscal Year
2013
Total Cost
$131,287
Indirect Cost
$8,074
Name
Seattle Biomedical Research Institute
Department
Type
DUNS #
070967955
City
Seattle
State
WA
Country
United States
Zip Code
98109
Gonçalves, Bronner P; Huang, Chiung-Yu; Morrison, Robert et al. (2014) Parasite burden and severity of malaria in Tanzanian children. N Engl J Med 370:1799-808
Harrington, Whitney E; Morrison, Robert; Fried, Michal et al. (2013) Intermittent preventive treatment in pregnant women is associated with increased risk of severe malaria in their offspring. PLoS One 8:e56183
Kabyemela, Edward; Gonçalves, Bronner P; Prevots, D Rebecca et al. (2013) Cytokine profiles at birth predict malaria severity during infancy. PLoS One 8:e77214
Harrington, Whitney E; Mutabingwa, Theonest K; Kabyemela, Edward et al. (2011) Intermittent treatment to prevent pregnancy malaria does not confer benefit in an area of widespread drug resistance. Clin Infect Dis 53:224-30
Kabyemela, Edward R; Fried, Michal; Kurtis, Jonathan D et al. (2008) Decreased susceptibility to Plasmodium falciparum infection in pregnant women with iron deficiency. J Infect Dis 198:163-6
Kabyemela, Edward R; Muehlenbachs, Atis; Fried, Michal et al. (2008) Maternal peripheral blood level of IL-10 as a marker for inflammatory placental malaria. Malar J 7:26
Kabyemela, Edward R; Fried, Michal; Kurtis, Jonathan D et al. (2008) Fetal responses during placental malaria modify the risk of low birth weight. Infect Immun 76:1527-34
Muehlenbachs, Atis; Mutabingwa, Theonest K; Fried, Michal et al. (2007) An unusual presentation of placental malaria: a single persisting nidus of sequestered parasites. Hum Pathol 38:520-3
Ntoumi, Francine; Kwiatkowski, Dominic P; Diakite, Mahamadou et al. (2007) New interventions for malaria: mining the human and parasite genomes. Am J Trop Med Hyg 77:270-5
Mutabingwa, Theonest K; Bolla, Melissa C; Li, Jin-Long et al. (2005) Maternal malaria and gravidity interact to modify infant susceptibility to malaria. PLoS Med 2:e407