The prevalence of Plasmodium vivax has been increasing lately, and the -70-80 million cases currently recorded annually are of growing global public health importance. However, research aimed at understanding this parasite species has lagged by comparison to that carried out for P. falciparum. This training program aims to enhance research on P. vivax malaria in Thailand, where P. vivax malaria has been on the rise and has become equally prevalent as P. falciparum. The overall training goal is to support Ph.D. students and postdoctoral fellows in P. vivax research and to transfer the state-of-the-art technologies to Thai scientists. The scientific objectives of the training plan address four areas of P. vivax malaria: 1) in vitro culture and cryopreservation techniques, 2) interactions between P. vivax and P. falciparum in natural infections, 3) parasite population diversity and molecular evolution, and 4) molecular biology, genomics and bioinformatics. The training will be conducted in Thailand through a double-track mechanism: 1) long-term training of Thai Ph.D. students and postdoctoral fellows, and 2) short-term training of Thai scientists through courses and workshops. Each trainee will be responsible for developing a research project in one of the four areas of P. vivax research by working closely with Thai and U.S. mentors. Mentors will provide continual guidance for their research and valuable training opportunities to promote career development of the trainees. A series of short training courses and workshops will be given in Thailand to provide the trainees with hands-on experience in P. vivax malaria research. The training program will also support trainees to come to the U.S. for short-term, research-oriented training in technologies needed for their research. To build a cadre of young scientists with long-term commitment and motivation in malaria research will be essential for sustaining strong interests in malaria research and, ultimately, for control of this disease in Thailand. Establishing this training mechanism in Thailand will have a significant impact on future training of malariologists in Asia.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW006571-03
Application #
7037490
Study Section
Special Emphasis Panel (ZRG1-ICP-2 (51))
Program Officer
Sina, Barbara J
Project Start
2004-07-19
Project End
2009-03-31
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
3
Fiscal Year
2006
Total Cost
$142,500
Indirect Cost
Name
Pennsylvania State University
Department
Zoology
Type
Schools of Earth Sciences/Natur
DUNS #
003403953
City
University Park
State
PA
Country
United States
Zip Code
16802
Bunditvorapoom, Duangkamon; Kochakarn, Theerarat; Kotanan, Namfon et al. (2018) Fitness Loss under Amino Acid Starvation in Artemisinin-Resistant Plasmodium falciparum Isolates from Cambodia. Sci Rep 8:12622
Mbenda, Huguette Gaelle Ngassa; Zeng, Weilin; Bai, Yao et al. (2018) Genetic diversity of the Plasmodium vivax phosphatidylinositol 3-kinase gene in two regions of the China-Myanmar border. Infect Genet Evol 61:45-52
Kittichai, Veerayuth; Koepfli, Cristian; Nguitragool, Wang et al. (2017) Substantial population structure of Plasmodium vivax in Thailand facilitates identification of the sources of residual transmission. PLoS Negl Trop Dis 11:e0005930
Nguitragool, Wang; Mueller, Ivo; Kumpitak, Chalermpon et al. (2017) Very high carriage of gametocytes in asymptomatic low-density Plasmodium falciparum and P. vivax infections in western Thailand. Parasit Vectors 10:512
Sriwichai, Patchara; Karl, Stephan; Samung, Yudthana et al. (2017) Imported Plasmodium falciparum and locally transmitted Plasmodium vivax: cross-border malaria transmission scenario in northwestern Thailand. Malar J 16:258
Zaw, Myo Thiha; Thant, Myo; Hlaing, Tin Maung et al. (2017) Asymptomatic and sub-microscopic malaria infection in Kayah State, eastern Myanmar. Malar J 16:138
Sriwichai, Patchara; Samung, Yudthana; Sumruayphol, Suchada et al. (2016) Natural human Plasmodium infections in major Anopheles mosquitoes in western Thailand. Parasit Vectors 9:17
Ponsuwanna, Patrath; Kochakarn, Theerarat; Bunditvorapoom, Duangkamon et al. (2016) Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites. Malar J 15:51
Sriwichai, Patchara; Karl, Stephan; Samung, Yudthana et al. (2015) Evaluation of CDC light traps for mosquito surveillance in a malaria endemic area on the Thai-Myanmar border. Parasit Vectors 8:636
Xia, Hui; Fang, Qiang; Jangpatarapongsa, Kulachart et al. (2015) A comparative study of natural immune responses against Plasmodium vivax C-terminal merozoite surface protein-1 (PvMSP-1) and apical membrane antigen-1 (PvAMA-1) in two endemic settings. EXCLI J 14:926-34

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