The prevalence of Plasmodium vivax has been increasing lately, and the -70-80 million cases currently recorded annually are of growing global public health importance. However, research aimed at understanding this parasite species has lagged by comparison to that carried out for P. falciparum. Lack of a suitable culture technique for this parasite is largely responsible for this. Therefore, this research aims to 1) develop a culture technique that is applicable to red cell invasion and drug resistance studies, 2) study the genetic diversity of this parasite in a hypoendemic area of Thailand, 3) elucidate the interaction of P. vivax and P. falciparum in terms of immunology and epidemiology, and 4) obtain comparative genomic information through analysis of the parasite proteomes. The proposed research will contribute to the understanding of Plamsodium vivax epidemiology and genetic diversity in an area where vivax malaria has been on the rise, therefore providing important information for control of the disease. In addition, this proposal targets will help build a cadre of young scientists with long-term commitment and motivation in malaria research in this area, which will have a more profound impact on future training of malariologists in Asia. ?

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW006571-04
Application #
7217972
Study Section
Special Emphasis Panel (ZRG1-ICP-2 (51))
Program Officer
Sina, Barbara J
Project Start
2004-07-19
Project End
2009-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
4
Fiscal Year
2007
Total Cost
$133,950
Indirect Cost
Name
Pennsylvania State University
Department
Zoology
Type
Schools of Earth Sciences/Natur
DUNS #
003403953
City
University Park
State
PA
Country
United States
Zip Code
16802
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Mbenda, Huguette Gaelle Ngassa; Zeng, Weilin; Bai, Yao et al. (2018) Genetic diversity of the Plasmodium vivax phosphatidylinositol 3-kinase gene in two regions of the China-Myanmar border. Infect Genet Evol 61:45-52
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Zaw, Myo Thiha; Thant, Myo; Hlaing, Tin Maung et al. (2017) Asymptomatic and sub-microscopic malaria infection in Kayah State, eastern Myanmar. Malar J 16:138
Sriwichai, Patchara; Samung, Yudthana; Sumruayphol, Suchada et al. (2016) Natural human Plasmodium infections in major Anopheles mosquitoes in western Thailand. Parasit Vectors 9:17
Ponsuwanna, Patrath; Kochakarn, Theerarat; Bunditvorapoom, Duangkamon et al. (2016) Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites. Malar J 15:51
Sriwichai, Patchara; Karl, Stephan; Samung, Yudthana et al. (2015) Evaluation of CDC light traps for mosquito surveillance in a malaria endemic area on the Thai-Myanmar border. Parasit Vectors 8:636
Xia, Hui; Fang, Qiang; Jangpatarapongsa, Kulachart et al. (2015) A comparative study of natural immune responses against Plasmodium vivax C-terminal merozoite surface protein-1 (PvMSP-1) and apical membrane antigen-1 (PvAMA-1) in two endemic settings. EXCLI J 14:926-34

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