Our Global Infectious Diseases Research Training Program builds upon over 25 years of collaboration between the University of Virginia (UVa) and the Federal University of Ceara (UFC) in Fortaleza, Brazil. Together we have identified key needs and gaps in research capacity and have developed and pursued research opportunities through our findings on the long-term effects of endemic enteric and parasitic infections. The continuing goal of this training program is to build relevant laboratory, clinical trials, and genetic epidemiology expertise to strengthen the capacity of the Federal University of Ceara, in order to provide critical new data to instruct policy and practice on controlling endemic enteric and parasitic infections and their lasting consequences. The GIDRT training program at UVa focuses upon genetic epidemiology and clinical trials, areas of priority identified in our needs assessment. Carefully selected fellows from UFC train at UVa under the mentorship of dedicated faculty. Their programs are enriched by interaction and collaboration with other international trainees and by special activities such as courses and colloquia in microbial pathogenesis, immunology, genetics, and clinical trials, a research-in-progress series, and a journal club. Our model of sustained international training and collaboration has resulted in 100% of our fellows returning home after training. Their continued research alliances with UVa faculty result in shared discoveries, patents, grants, and publications (over 200 to date). All too often international training results in opportunities for overseas physicians and scientists to move permanently to the US (the "brain drain"). Our strongly articulated philosophy and documented track record is precisely the opposite: to attract the brightest and most innovative researchers who are strongly committed to returning home after their training because the opportunities for further progress on their global infectious disease research priorities are greatest in their home countries.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW006578-10
Application #
8248774
Study Section
Special Emphasis Panel (ZRG1-ICP2-B (51))
Program Officer
Sina, Barbara J
Project Start
2003-09-05
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2014-03-31
Support Year
10
Fiscal Year
2012
Total Cost
$139,862
Indirect Cost
$10,360
Name
University of Virginia
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Azevedo, Orleâncio G R; Bolick, David T; Roche, James K et al. (2014) Apolipoprotein E plays a key role against cryptosporidial infection in transgenic undernourished mice. PLoS One 9:e89562
Bolick, David T; Chen, Tufeng; Alves, Luís Antonio O et al. (2014) Intestinal cell kinase is a novel participant in intestinal cell signaling responses to protein malnutrition. PLoS One 9:e106902
Santos, Ana A Q A; Braga-Neto, Manuel B; Oliveira, Marcelo R et al. (2013) Glutamine and alanyl-glutamine increase RhoA expression and reduce Clostridium difficile toxin-a-induced intestinal epithelial cell damage. Biomed Res Int 2013:152052
Rodrigues, Raphael S; Oliveira, Renato A C; Li, Yuesheng et al. (2013) Intestinal epithelial restitution after TcdB challenge and recovery from Clostridium difficile infection in mice with alanyl-glutamine treatment. J Infect Dis 207:1505-15
Medeiros, Pedro; Bolick, David T; Roche, James K et al. (2013) The micronutrient zinc inhibits EAEC strain 042 adherence, biofilm formation, virulence gene expression, and epithelial cytokine responses benefiting the infected host. Virulence 4:624-33
Joventino, Emanuella S; Ximenes, Lorena B; Almeida, Paulo C et al. (2013) The maternal self-efficacy scale for preventing early childhood diarrhea: validity and reliability. Public Health Nurs 30:150-8
Guerrant, Richard L; DeBoer, Mark D; Moore, Sean R et al. (2013) The impoverished gut--a triple burden of diarrhoea, stunting and chronic disease. Nat Rev Gastroenterol Hepatol 10:220-9
Roche, James K; Rojo, Ana Lara; Costa, Lourrany B et al. (2013) Intranasal vaccination in mice with an attenuated Salmonella enterica Serovar 908htr A expressing Cp15 of Cryptosporidium: impact of malnutrition with preservation of cytokine secretion. Vaccine 31:912-8
Lima, Ila Fernanda Nunes; Boisen, Nadia; Quetz, Josiane da Silva et al. (2013) Prevalence of enteroaggregative Escherichia coli and its virulence-related genes in a case-control study among children from north-eastern Brazil. J Med Microbiol 62:683-93
Costa, Lourrany B; Noronha, Francisco Jose; Roche, James K et al. (2012) Novel in vitro and in vivo models and potential new therapeutics to break the vicious cycle of Cryptosporidium infection and malnutrition. J Infect Dis 205:1464-71

Showing the most recent 10 out of 20 publications