Infectious Disease Research Training Program in Peru. Background. Over the past 15 years we have developed a research network in Peru that combines state-of-the-art research with high-quality training. This collaboration between UPCH, A.B.PRISMA, international trainers and JHU mentors people as they progress from trainee to independent scientist and in turn themselves become trainers. Over the past 10 years, this NIH funded network has trained 94 Peruvians, 37 of whom have been funded to study at US universities. Importantly, all of the MSc and PhDs remain based in Peru. This strengthening of Peruvian research expertise has also been achieved by training 158 visitors from other countries, three of who have consequently moved to Peru, where they now lead research and training. Over 10 years this has resulted in over 150 trainee publications directly related to this research. Proposed training principles: This grant would allow our training network to further expand, building upon its internationally recognized strengths whilst increasing accessibility for candidates from disadvantaged regions and introducing a curriculum of core subjects taught in regular seminars. Specifically, we would continue to maximize trainee growth through: . One-to-one mentorship from local, visiting and returning experts . Achievement-driven stepwise progression for those with greatest ability . Respect for equality of opportunity irrespective of gender and ethnicity. Proposed training structure: This network will continue to be broad-based (numbers are for 5 years): 1. Mentorship in Peru will remain the foundation of this program. Bright candidates will be selected for one-to-one mentorship from a trainer within the apprenticeship setting of a research project (approximately 100). 2. Peru formal training will constitute laboratory, rotations and one-week long training seminars (approximately 250). 3. Peru MSc training for the most able candidates selected by their mentor and trainers (10). 4. USA diploma (10), MPH (1) and PhD (2) training at JHU will be provided for the highest achievers who are judged to have potential to become independent scientists and trainers. This grant will facilitate the growth and enhancement of this effective and egalitarian training network, allowing physicians and scientists to both benefit from and contribute to the sustainable development of infectious disease research in Peru and other countries.

National Institute of Health (NIH)
Fogarty International Center (FIC)
International Research Training Grants (D43)
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Special Emphasis Panel (ZRG1-ICP2-B (51))
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Sina, Barbara J
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Johns Hopkins University
Public Health & Prev Medicine
Schools of Public Health
United States
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Clark, Eva H; Sherbuk, Jackie; Okamoto, Emi et al. (2014) Hyperendemic Chagas disease and the unmet need for pacemakers in the Bolivian Chaco. PLoS Negl Trop Dis 8:e2801
Salazar-Salinas, Karim; Baldera-Aguayo, Pedro A; Encomendero-Risco, Jimy J et al. (2014) Metal-ion effects on the polarization of metal-bound water and infrared vibrational modes of the coordinated metal center of Mycobacterium tuberculosis pyrazinamidase via quantum mechanical calculations. J Phys Chem B 118:10065-75
Okamoto, Emi E; Sherbuk, Jacqueline E; Clark, Eva H et al. (2014) Biomarkers in Trypanosoma cruzi-infected and uninfected individuals with varying severity of cardiomyopathy in Santa Cruz, Bolivia. PLoS Negl Trop Dis 8:e3227
Castro-Sesquen, Yagahira E; Gilman, Robert H; Yauri, Veronica et al. (2013) Detection of soluble antigen and DNA of Trypanosoma cruzi in urine is independent of renal injury in the guinea pig model. PLoS One 8:e58480
Sheen, Patricia; Lozano, Katherine; Gilman, Robert H et al. (2013) pncA gene expression and prediction factors on pyrazinamide resistance in Mycobacterium tuberculosis. Tuberculosis (Edinb) 93:515-22
Castro-Sesquen, Yagahira E; Gilman, Robert H; Paico, Henry et al. (2013) Cell death and serum markers of collagen metabolism during cardiac remodeling in Cavia porcellus experimentally infected with Trypanosoma cruzi. PLoS Negl Trop Dis 7:e1996
Chile, Nancy; Evangelista, Julio; Gilman, Robert H et al. (2012) Standardization of a fluorescent-based quantitative adhesion assay to study attachment of Taenia solium oncosphere to epithelial cells in vitro. J Immunol Methods 376:89-96
Zimic, Mirko; Fuentes, Patricia; Gilman, Robert H et al. (2012) Pyrazinoic acid efflux rate in Mycobacterium tuberculosis is a better proxy of pyrazinamide resistance. Tuberculosis (Edinb) 92:84-91
Suzuki, Masato; Kiga, Kotaro; Kersulyte, Dangeruta et al. (2011) Attenuated CagA oncoprotein in Helicobacter pylori from Amerindians in Peruvian Amazon. J Biol Chem 286:29964-72
Arriola, Carmen S; Guere, Mariella E; Larsen, Jesper et al. (2011) Presence of methicillin-resistant Staphylococcus aureus in pigs in Peru. PLoS One 6:e28529

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