The Dartmouth/Boston University AIDS International Training and Research Program (AITRP) is a 5-year comprehensive program designed to provide diverse degree and non-degree training to Tanzanian scientists with the overall goal of strengthening research capacity in HIV and tuberculosis at the Muhimbili University College of Health Sciences. This AITRP builds on an existing and successful collaboration which has launched the first efficacy trial for a vaccine against tuberculosis among persons with HIV infection. This collaboration has identified critical training needs and has defined key research objectives for positioning Tanzanian scientists to continue to develop and apply programs to control both HIV and tuberculosis. This AITRP is based on a sequenced plan of training and subsequent research mentored by recognized experts in international public health, health outcomes research, behavioral science, immunology, HIV, tuberculosis and vaccine research. The Program will enhance research capacity in all basic areas (e.g. epidemiology, clinical trials) and will also provide innovative training in new and specialized areas (e.g., mucosal immunity, evaluative clinical sciences) to facilitate the growth and development of novel research projects relevant to the prevention of HIV and tuberculosis in developing countries. The Program will be closely managed by a core faculty group at the three academic institutions with extensive experience in international health training and a strong commitment to ensuring the long-term benefits of the Program for Tanzania. A detailed plan provides for increasing transfer of training and research to Tanzania over the 5-year duration of the Program and for continuous re-evaluation of Program priorities. Guidance and oversight will be provided by a Training Advisory Group with outstanding credentials in international punic health.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
3D43TW006807-10S2
Application #
8725804
Study Section
Special Emphasis Panel (ZRG1-BDA-K (50))
Program Officer
Mcdermott, Jeanne
Project Start
2003-09-23
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2014-05-31
Support Year
10
Fiscal Year
2013
Total Cost
$200,000
Indirect Cost
Name
Dartmouth College
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
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Maro, Isaac I; Moshi, Ndeserua; Clavier, Odile H et al. (2014) Auditory impairments in HIV-infected individuals in Tanzania. Ear Hear 35:306-17
Adams, Lisa V; McQuillan, Thomas; Naburi, Helga E et al. (2014) Diagnosis and treatment of tuberculosis among children at an HIV care program in Dar es Salaam, Tanzania. Pediatr Infect Dis J 33:1234-6
Lahey, Timothy; Czechura, Tom; Crabtree, Scott et al. (2013) Greater preexisting interferon ýý responses to mycobacterial antigens and lower bacillary load during HIV-associated tuberculosis. J Infect Dis 208:1629-33
Kabali, Conrad; Mtei, Lillian; Brooks, Daniel R et al. (2013) Increased mortality associated with treated active tuberculosis in HIV-infected adults in Tanzania. Tuberculosis (Edinb) 93:461-6
Talbot, Elizabeth; Munseri, Patricia; Teixeira, Pedro et al. (2012) Test characteristics of urinary lipoarabinomannan and predictors of mortality among hospitalized HIV-infected tuberculosis suspects in Tanzania. PLoS One 7:e32876
von Reyn, C F; Bakari, M; Arbeit, R D et al. (2012) New vaccines for the prevention of tuberculosis in human immunodeficiency virus infection. Int J Tuberc Lung Dis 16:718-23
Lahey, Timothy; Mitchell, Brian K; Arbeit, Robert D et al. (2011) Polyantigenic interferon-? responses are associated with protection from TB among HIV-infected adults with childhood BCG immunization. PLoS One 6:e22074
Munseri, Patricia J; Talbot, Elizabeth A; Bakari, Muhammad et al. (2011) The bacteraemia of disseminated tuberculosis among HIV-infected patients with prolonged fever in Tanzania. Scand J Infect Dis 43:696-701
von Reyn, C F; Kimambo, S; Mtei, L et al. (2011) Disseminated tuberculosis in human immunodeficiency virus infection: ineffective immunity, polyclonal disease and high mortality. Int J Tuberc Lung Dis 15:1087-92

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