Tuberculosis (TB) has emerged as an enormous public health problem in the independent and democratic country of Georgia, a former Soviet republic. High rates of multidrug resistant (MDR)-TB have been demonstrated in Georgia in large part through investigations carried out by Fogarty trainees supported by the Emory-Georgia TB Research Training Program (EGTB-RTP). TB control efforts are further challenged by the emergence of extensive drug resistant (XDR)-TB in Georgia. Considerable progress has been made in establishing a solid foundation to support TB research in Georgia over the past four years. This renewal application for the EGTB-RTP is submitted to obtain additional funding to build upon the achievements made in the first grant cycle and further expand the in-country TB research and public health infrastructure and capacity which will allow Georgian investigators to carry out internationally relevant TB-related research and translate research findings into practice and public policy in Georgia.
Specific aims of this application include: 1) To continue to build human resource capacity and enhance the research infrastructure for high quality TB-related research in Georgia by providing long, medium and short-term research training and research opportunities;this includes opportunities for research training in relevant laboratory, clinical, epidemiologic and social science TB-related research;2) To transition the focus of TB-related research training to in-country training in Georgia;3) To enhance and greatly expand the capacity to carry out TB-related translational research in Georgia (including Tl "bench to beside" research and T2 and T3 "bedside to community" research which includes Implementation Science research);4) To enhance in-country research ethics training in Georgia;and 5) To enhance opportunities for multidisciplinary TB-related research and collaboration among investigators and among several key institutions in Georgia including the National Center for Tuberculosis and Lung Disease/National TB Program;the National Center for Disease Control and Public Health;the Infectious Diseases, AIDS, and Clinical Immunology Research Center;and Tbilisi State Medical University.

Public Health Relevance

By building TB research capacity in Georgia, trainees will be able to enhance the public health infrastructure through translation of research into practice and public policy. In addition, they will be capable of conducting high quality internationally-recognized research including translational research and Implementation Science research. This will allow better targeting of funds from the Global Fund and other programs.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW007124-09
Application #
8284348
Study Section
Special Emphasis Panel (ZRG1-ICP2-B (51))
Program Officer
Sina, Barbara J
Project Start
2004-09-27
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
9
Fiscal Year
2012
Total Cost
$195,460
Indirect Cost
$12,812
Name
Emory University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
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Kipiani, Maia; Mirtskhulava, Veriko; Tukvadze, Nestani et al. (2014) Significant clinical impact of a rapid molecular diagnostic test (Genotype MTBDRplus assay) to detect multidrug-resistant tuberculosis. Clin Infect Dis 59:1559-66
Chkhartishvili, Nikoloz; Sharvadze, Lali; Chokoshvili, Otar et al. (2014) Mortality and causes of death among HIV-infected individuals in the country of Georgia: 1989-2012. AIDS Res Hum Retroviruses 30:560-6
Chakhaia, Tsira; Magee, Matthew J; Kempker, Russell R et al. (2014) High utility of contact investigation for latent and active tuberculosis case detection among the contacts: a retrospective cohort study in Tbilisi, Georgia, 2010-2011. PLoS One 9:e111773
Magee, Matthew J; Kempker, Russell R; Kipiani, Maia et al. (2014) Diabetes mellitus, smoking status, and rate of sputum culture conversion in patients with multidrug-resistant tuberculosis: a cohort study from the country of Georgia. PLoS One 9:e94890
Tukvadze, N; Bablishvili, N; Apsindzelashvili, R et al. (2014) Performance of the MTBDRsl assay in Georgia. Int J Tuberc Lung Dis 18:233-9
Frediani, Jennifer K; Jones, Dean P; Tukvadze, Nestan et al. (2014) Plasma metabolomics in human pulmonary tuberculosis disease: a pilot study. PLoS One 9:e108854
Rabin, A S; Kuchukhidze, G; Sanikidze, E et al. (2013) Prescribed and self-medication use increase delays in diagnosis of tuberculosis in the country of Georgia. Int J Tuberc Lung Dis 17:214-20
Whitaker, Jennifer A; A Whitaker, Jennifer; Mirtskhulava, Veriko et al. (2013) Prevalence and incidence of latent tuberculosis infection in georgian healthcare workers. PLoS One 8:e58202
Vashakidze, Sergo; Gogishvili, Shota; Nikolaishvili, Ketino et al. (2013) Favorable outcomes for multidrug and extensively drug resistant tuberculosis patients undergoing surgery. Ann Thorac Surg 95:1892-8

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