Tuberculosis (TB) has emerged as an enormous public health problem in the independent and democratic country of Georgia, a former Soviet republic. High rates of multidrug resistant (MDR)-TB have been demonstrated in Georgia in large part through investigations carried out by Fogarty trainees supported by the Emory-Georgia TB Research Training Program (EGTB-RTP). TB control efforts are further challenged by the emergence of extensive drug resistant (XDR)-TB in Georgia. Considerable progress has been made in establishing a solid foundation to support TB research in Georgia over the past four years. This renewal application for the EGTB-RTP is submitted to obtain additional funding to build upon the achievements made in the first grant cycle and further expand the in-country TB research and public health infrastructure and capacity which will allow Georgian investigators to carry out internationally relevant TB-related research and translate research findings into practice and public policy in Georgia.
Specific aims of this application include: 1) To continue to build human resource capacity and enhance the research infrastructure for high quality TB-related research in Georgia by providing long, medium and short-term research training and research opportunities;this includes opportunities for research training in relevant laboratory, clinical, epidemiologic and social science TB-related research;2) To transition the focus of TB-related research training to in-country training in Georgia;3) To enhance and greatly expand the capacity to carry out TB-related translational research in Georgia (including Tl "bench to beside" research and T2 and T3 "bedside to community" research which includes Implementation Science research);4) To enhance in-country research ethics training in Georgia;and 5) To enhance opportunities for multidisciplinary TB-related research and collaboration among investigators and among several key institutions in Georgia including the National Center for Tuberculosis and Lung Disease/National TB Program;the National Center for Disease Control and Public Health;the Infectious Diseases, AIDS, and Clinical Immunology Research Center;and Tbilisi State Medical University.
By building TB research capacity in Georgia, trainees will be able to enhance the public health infrastructure through translation of research into practice and public policy. In addition, they will be capable of conducting high quality internationally-recognized research including translational research and Implementation Science research. This will allow better targeting of funds from the Global Fund and other programs.
|Baliashvili, Davit; Magee, Matthew J; Kempker, Russell R et al. (2016) Contacts of retreatment tuberculosis cases with a prior poor treatment outcome are at increased risk of latent tuberculosis infection. Int J Infect Dis 43:49-50|
|Frediani, Jennifer K; Sanikidze, Ekaterina; Kipiani, Maia et al. (2016) Macronutrient intake and body composition changes during anti-tuberculosis therapy in adults. Clin Nutr 35:205-12|
|Abutidze, A; Bolokadze, N; Chkhartishvili, N et al. (2016) INCIDENCE OF TUBERCULOSIS AMONG HIV/HCV CO-INFECTED PATIENTS RECEIVING HEPATITIS C TREATMENT WITH PEGYLATED INTERFERON AND RIBAVIRIN IN GEORGIA. Georgian Med News :10-5|
|Salindri, Argita D; Kipiani, Maia; Kempker, Russell R et al. (2016) Diabetes Reduces the Rate of Sputum Culture Conversion in Patients With Newly Diagnosed Multidrug-Resistant Tuberculosis. Open Forum Infect Dis 3:ofw126|
|Bablishvili, N; Tukvadze, N; Avaliani, Z et al. (2015) A comparison of the Xpert(Â®) MTB/RIF and GenoType(Â®) MTBDRplus assays in Georgia. Int J Tuberc Lung Dis 19:676-8|
|Van't Hoog, A H; Bergval, I; Tukvadze, N et al. (2015) The potential of a multiplex high-throughput molecular assay for early detection of first and second line tuberculosis drug resistance mutations to improve infection control and reduce costs: a decision analytical modeling study. BMC Infect Dis 15:473|
|Kempker, Russell R; Kipiani, Maia; Mirtskhulava, Veriko et al. (2015) Acquired Drug Resistance in Mycobacterium tuberculosis and Poor Outcomes among Patients with Multidrug-Resistant Tuberculosis. Emerg Infect Dis 21:992-1001|
|Tukvadze, Nestan; Sanikidze, Ekaterina; Kipiani, Maia et al. (2015) High-dose vitamin D3 in adults with pulmonary tuberculosis: a double-blind randomized controlled trial. Am J Clin Nutr 102:1059-69|
|Kempker, Russell R; Barth, Aline B; Vashakidze, Sergo et al. (2015) Cavitary penetration of levofloxacin among patients with multidrug-resistant tuberculosis. Antimicrob Agents Chemother 59:3149-55|
|Gegia, Medea; Magee, Matthew J; Kempker, Russell R et al. (2015) Tobacco smoking and tuberculosis treatment outcomes: a prospective cohort study in Georgia. Bull World Health Organ 93:390-9|
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