The Immunology Service of the Federal University of Bahia has ongoing research programs on endemic tropical diseases (leishmaniasis, schistosomiasis, HTLV-1) in collaboration with US and other Brazilian institutions aimed at: 1) Characterizing the immune response to these pathogens, 2) Correlating immunological response with clinical manifestations of these diseases, 3) Studying genetic contributions to disease outcome, 4) Identifying new forms of therapy and control measures, and 5) Identifying pathogen components that interfere in disease outcome. The Federal University of Bahia has taken advantage of its collaboration with Cornell University in the past, through training of young investigators in Fogarty-sponsored Training Programs. Although the Immunology Service receives support for research (including a TMRC, NIH grant), there is no specific support for addressing training needs required to implement these projects. The present proposal will use needs identified in the studies of leishmaniasis to address the following specific aims: 1) To create training opportunities in areas such as genetics, disease pathogenesis, clinical investigation and ethics, 2) To disseminate training to other investigators from Bahia and other universities of Brazil. To address the first aim this program emphasizes collaboration with foreign universities (Cornell University, University of Iowa, Johns Hopkins, University of Pennsylvania, Cambridge University) for longterm training of post-doctoral fellows (total of 5) and short-term advanced training for young and senior investigators (total of 5) to address the specific needs in expertise within the specified areas.
The second aim will be addressed by using the in-country expertise and resources and the advanced trained mentors to provide training for graduate, post-graduate students, young investigators, physicians and technicians in areas such as basic and clinical immunology, immunotherapy, molecular and clinical epidemiology, as well as in the new areas specified above after the training of the Brazilian mentors.
|Oliveira, Joyce Moura; Rêgo, Jamile Leão; de Lima Santana, Nadja et al. (2016) The -308 bp TNF gene polymorphism influences tumor necrosis factor expression in leprosy patients in Bahia State, Brazil. Infect Genet Evol 39:147-154|
|Andrade, Rosana C P; Neto, José A; Andrade, Luciana et al. (2016) Effects of Physiotherapy in the Treatment of Neurogenic Bladder in Patients Infected With Human T-Lymphotropic Virus 1. Urology 89:33-8|
|Castellucci, Léa Cristina; Almeida, Lucas Frederico de; Jamieson, Sarra Elisabeth et al. (2014) Host genetic factors in American cutaneous leishmaniasis: a critical appraisal of studies conducted in an endemic area of Brazil. Mem Inst Oswaldo Cruz 109:279-88|
|Castellucci, Lea; Jamieson, Sarra E; Almeida, Lucas et al. (2012) Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil. Infect Genet Evol 12:1102-10|
|Castellucci, L; Jamieson, S E; Miller, E N et al. (2011) FLI1 polymorphism affects susceptibility to cutaneous leishmaniasis in Brazil. Genes Immun 12:589-94|
|Newlove, Tracey; Guimarães, Luiz H; Morgan, Daniel J et al. (2011) Antihelminthic therapy and antimony in cutaneous leishmaniasis: a randomized, double-blind, placebo-controlled trial in patients co-infected with helminths and Leishmania braziliensis. Am J Trop Med Hyg 84:551-5|
|Ramasawmy, Rajendranath; Menezes, Eliane; Magalhaes, Andrea et al. (2010) The -2518bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil. Infect Genet Evol 10:607-13|
|Castellucci, Lea; Jamieson, Sarra E; Miller, E Nancy et al. (2010) CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study. BMC Med Genet 11:10|
|Passos, Sara T; Silver, Jonathan S; O'Hara, Aisling C et al. (2010) IL-6 promotes NK cell production of IL-17 during toxoplasmosis. J Immunol 184:1776-83|
|Souza, Anselmo S; Giudice, Angela; Pereira, Julia Mb et al. (2010) Resistance of Leishmania (Viannia) braziliensis to nitric oxide: correlation with antimony therapy and TNF-alpha production. BMC Infect Dis 10:209|
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