The training of biomedical scientists from Brazil continues to be the focus of the renewal of this training grant. Scientists at Einstein have well established long standing research collaborations with Brazil. This grant has now trained over 20 individuals from Brazil on research techniques for infectious diseases. This training has and will continue to enhance the capabilities to combat the intractable infectious diseases endemic in Brazil. The proposed renewal of this training program will build upon the successes of the previous granting period. The goal of this renewal application is to harness state-of-the-art scientific knowledge and technical skills to augment programs to prevent, treat and control the major infectious diseases causing significant morbidity and mortality in Brazil. We will focus on infections endemic to Brazil for which there are existing collaborative interactions between Brazilian scientists and institutions and the scientists at The Albert Einstein College of Medicine. The participating Brazilian co-mentors are at the Federal Universities of Rio de Janeiro Minas Gerais and Sao Paulo, and the Foundation Oswaldo Cruz (FIOCRUZ). The diseases included in this training program are: fungal diseases (i.e., histoplasmosis, sporotrichosis) parasitic diseases (Chagas disease, toxoplasmosis and malaria) and bacterial diseases (legionnaire's disease and tuberculosis) which are endemic to Brazil. The proposed training program includes both didactic and laboratory components, as well as a formal course in ethics and the responsible conduct of research. Participants will include those coming for either short or long term periods of time, predoctoral students and post-doctoral fellows. Our renewal application is innovative in its use of the established research collaborations and education programs at Einstein. In addition, our research program crosses traditional institutional lines and is set up as a thematic approach involving more than one institution. We believe that this training program will contribute significantly to the long term goal of building sustainable research capacity in the relevant endemic infectious diseases of Brazil.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW007129-09
Application #
8292052
Study Section
Special Emphasis Panel (ZRG1-ICP2-B (51))
Program Officer
Sina, Barbara J
Project Start
2004-07-19
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
9
Fiscal Year
2012
Total Cost
$195,460
Indirect Cost
$11,461
Name
Albert Einstein College of Medicine
Department
Pathology
Type
Schools of Medicine
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
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Martins, Yuri C; Freeman, Brandi D; Akide Ndunge, Oscar B et al. (2016) Endothelin-1 Treatment Induces an Experimental Cerebral Malaria-Like Syndrome in C57BL/6 Mice Infected with Plasmodium berghei NK65. Am J Pathol 186:2957-2969
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Martins, Yuri C; Tanowitz, Herbert B; Kazacos, Kevin R (2015) Central nervous system manifestations of Angiostrongylus cantonensis infection. Acta Trop 141:46-53
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de Matos Guedes, Herbert Leonel; da Silva Costa, Beatriz Lilian; Chaves, Suzana Passos et al. (2014) Intranasal vaccination with extracellular serine proteases of Leishmania amazonensis confers protective immunity to BALB/c mice against infection. Parasit Vectors 7:448
Machado, Juliana Reis; Soave, Danilo Figueiredo; da Silva, Marcos Vinícius et al. (2014) Neonatal sepsis and inflammatory mediators. Mediators Inflamm 2014:269681
da Silva-Souza, Hercules A; de Lira, Maria Nathália; Patel, Naman K et al. (2014) Inhibitors of the 5-lipoxygenase pathway activate pannexin1 channels in macrophages via the thromboxane receptor. Am J Physiol Cell Physiol 307:C571-9

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