This is a competitive renewal application to support continuation of a training program in malaria research begun in Uganda in 2000.
Aims of our program will be: 1) to increase the expertise of our trainees in relevant clinical, epidemiological, and molecular research on malaria, 2) to strengthen the sustainability of malaria research in Uganda, 3) to expand research interactions between Ugandan and American scientists, 4) to strengthen trainee contributions to evidence-based decision-making, 5) to optimize training through utilization of additional available resources in Uganda, and 6) to strengthen research capacity in Uganda by helping trainees to integrate into Ugandan institutions and pursue independently-supported scientific careers.Trainees will be chosen among Ugandan junior scientists with interests in malaria research, and will enter either clinical, epidemiology, or molecular research tracks. When possible, training will be linked to ongoing research projects in Uganda. Formal training will be principally at the Masters level, although some more advanced training at the PhD or postdoctoral level will also be available. Training will be available at Makerere University in Kampala, Uganda, at the University of California, San Francisco and Berkeley, and in sandwich programs involving multiple institutions.

Public Health Relevance

This program will train Ugandan junior investigators in clinical malaria research. The program will be highly relevant, as an improved infrastructure for research on malaria is needed in countries endemic for this disease. A key part of this improved infrastructure is a growing base of research experts, as will be facilitated for Uganda by this award.

National Institute of Health (NIH)
Fogarty International Center (FIC)
International Research Training Grants (D43)
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Special Emphasis Panel (ZRG1-ICP2-B (50))
Program Officer
Sina, Barbara J
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University of California San Francisco
Internal Medicine/Medicine
Schools of Medicine
San Francisco
United States
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Walakira, Andrew; Tukwasibwe, Stephen; Kiggundu, Moses et al. (2017) Marked variation in prevalence of malaria-protective human genetic polymorphisms across Uganda. Infect Genet Evol 55:281-287
Ssewanyana, Isaac; Arinaitwe, Emmanuel; Nankabirwa, Joaniter I et al. (2017) Avidity of anti-malarial antibodies inversely related to transmission intensity at three sites in Uganda. Malar J 16:67
Cooper, Roland A; Conrad, Melissa D; Watson, Quentin D et al. (2015) Lack of Artemisinin Resistance in Plasmodium falciparum in Uganda Based on Parasitological and Molecular Assays. Antimicrob Agents Chemother 59:5061-4
Tumwebaze, Patrick; Conrad, Melissa D; Walakira, Andrew et al. (2015) Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children. Antimicrob Agents Chemother 59:3018-30
Nankabirwa, Joaniter I; Wandera, Bonnie; Amuge, Pauline et al. (2014) Impact of intermittent preventive treatment with dihydroartemisinin-piperaquine on malaria in Ugandan schoolchildren: a randomized, placebo-controlled trial. Clin Infect Dis 58:1404-12
Kakuru, Abel; Achan, Jane; Muhindo, Mary K et al. (2014) Artemisinin-based combination therapies are efficacious and safe for treatment of uncomplicated malaria in HIV-infected Ugandan children. Clin Infect Dis 59:446-53
Tukwasibwe, Stephen; Mugenyi, Levi; Mbogo, George W et al. (2014) Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in Uganda. J Infect Dis 210:154-7
Nankoberanyi, Sheila; Mbogo, George W; LeClair, Norbert P et al. (2014) Validation of the ligase detection reaction fluorescent microsphere assay for the detection of Plasmodium falciparum resistance mediating polymorphisms in Uganda. Malar J 13:95
Mbogo, George W; Nankoberanyi, Sheila; Tukwasibwe, Stephen et al. (2014) Temporal changes in prevalence of molecular markers mediating antimalarial drug resistance in a high malaria transmission setting in Uganda. Am J Trop Med Hyg 91:54-61
Nankabirwa, Joaniter; Wandera, Bonnie; Kiwanuka, Noah et al. (2013) Asymptomatic Plasmodium infection and cognition among primary schoolchildren in a high malaria transmission setting in Uganda. Am J Trop Med Hyg 88:1102-8

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