The aim of this project is to provide research training regarding several species of malaria parasite of the genus Plasmodium, in order to build sustainable research capacity at a laboratory within the National Institute of Malaria Research (NIMR) in Delhi, India. Two species of malaria parasite in particular, P. falciparum and P. vivax, cause significant morbidity and some mortality in the Indian sub-continent. Thus Plasmodium biology provides an ideal focus for research that will both enhance prevention, treatment and control of this infectious disease, as well as providing a focal point for building sustainable infectious disease research capacity at an institution within a developing country. Members of the U.S. institution, the Department of Medical Parasitology at New York University School of Medicine, have a long history of research collaboration with the NIMR in Delhi, and can provide the complementary skills and expertise necessary for a collaborative research training program. At the core of this proposal is the education and instruction of five trainees (three pre-doctoral students, one post-doctoral fellow and one non-degree attaining trainee) at NIMR by a group of U.S and Indian mentors and faculty with expertise in various areas of Plasmodium biology. The topics of training will include: population diversity and genetics, molecular evolution, genetic association studies, in vitro culture, bioinformatics, genomics, mosquito transmission studies, and adjunct skills such as scientific presentation, grant writing, use of the scientific literature, and training in the responsible conduct of research. This research project will promote research into a major public health problem in India, the malaria parasite Plasmodium. By encouraging research in the prevention, treatment and control of this vector-borne pathogen, we hope to generate a focal point for building sustainable infectious disease capacity at an institution in a developing country.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW007884-04
Application #
7796724
Study Section
Special Emphasis Panel (ZRG1-ICP2-B (50))
Program Officer
Sina, Barbara J
Project Start
2007-06-01
Project End
2012-03-31
Budget Start
2010-04-01
Budget End
2011-03-31
Support Year
4
Fiscal Year
2010
Total Cost
$133,500
Indirect Cost
Name
New York University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
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Kar, Narayani Prasad; Kumar, Ashwani; Singh, Om P et al. (2014) A review of malaria transmission dynamics in forest ecosystems. Parasit Vectors 7:265
Shalini, Sneh; Chaudhuri, Saumyadripta; Sutton, Patrick L et al. (2014) Chloroquine efficacy studies confirm drug susceptibility of Plasmodium vivax in Chennai, India. Malar J 13:129
Prajapati, Surendra K; Joshi, Hema; Carlton, Jane M et al. (2013) Neutral polymorphisms in putative housekeeping genes and tandem repeats unravels the population genetics and evolutionary history of Plasmodium vivax in India. PLoS Negl Trop Dis 7:e2425
Mallick, Prashant K; Sutton, Patrick L; Singh, Ruchi et al. (2013) Microsatellite analysis of chloroquine resistance associated alleles and neutral loci reveal genetic structure of Indian Plasmodium falciparum. Infect Genet Evol 19:164-75
Carlton, Jane M; Das, Aparup; Escalante, Ananias A (2013) Genomics, population genetics and evolutionary history of Plasmodium vivax. Adv Parasitol 81:203-22
Das, Aparup; Anvikar, Anupkumar R; Cator, Lauren J et al. (2012) Malaria in India: the center for the study of complex malaria in India. Acta Trop 121:267-73
Mallick, Prashant K; Joshi, Hema; Valecha, Neena et al. (2012) Mutant pfcrt ""SVMNT"" haplotype and wild type pfmdr1 ""N86"" are endemic in Plasmodium vivax dominated areas of India under high chloroquine exposure. Malar J 11:16
Prajapati, Surendra K; Kumari, Pragati; Singh, Om P (2012) Molecular analysis of reticulocyte binding protein-2 gene in Plasmodium vivax isolates from India. BMC Microbiol 12:243
Laishram, Dolie D; Sutton, Patrick L; Nanda, Nutan et al. (2012) The complexities of malaria disease manifestations with a focus on asymptomatic malaria. Malar J 11:29

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