This Global Infectious Disease Research Training Program research training proposal is submitted jointly by faculty of the Center for Tropical and Emerging Global Diseases (CTEGD) at the University of Georgia (UGA) and faculty of the Institute of Biotechnological Investigations (IIB/INTECH) at the National University of General San Martin (UNSAM), Argentina. The focus of this proposal is to expand the parasitic disease research capacity at the IIB/INTECH to provide training opportunities for participants at that Institution within the context of ongoing and future U.S. research collaborations. The Training Program in Parasitic Diseases at the IIB/INTECH centers on the Training Program in Molecular Biology and Biotechnology of this public institution. The Director of this program is the proposed Co-Program Director, with whom the Program Director of this application has a long term collaboration. The research areas in which the trainees will work refer to diseases of considerable importance in Argentina: Chagas'disease, leishmaniases and toxoplasmosis. The research lines range from basic studies on the biochemistry and molecular biology of the pathogens, and the host/parasite relationship, to very applied aspects, like the development of new diagnostic kits, and vaccines. This training proposal is founded on NIH P01 and R01 grants and other funded projects held collaboratively between UGA and IIB/INTECH scientists. These projects have already demonstrated the ability of UGA/IIB/INTECH scientists to jointly pursue productive research and train predoctoral and postdoctoral students. The IIB/INTECH scientists will work with internationally recognized scientists at UGA who have demonstrated outstanding training skills. Educational experiences for predoctoral trainees will focus on appropriate course work and in depth thesis research. Postdoctoral training will focus on research. Students will participate in journal clubs, seminars, scientific meetings and short-term overseas opportunities, and will learn aspects of parasitology outside of their own research focus, as well as research integrity. IIB/INTECH has most of the basic installations and equipment required for modern research in biochemistry, molecular and cell biology. The UGA is a leading center for graduate education and has outstanding facilities and resources available to students and faculty. Funding is requested for 5 years to support 5 predoctoral and 2 postdoctoral trainees per year.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW007888-03
Application #
7627313
Study Section
Special Emphasis Panel (ZRG1-ICP2-B (50))
Program Officer
Sina, Barbara J
Project Start
2007-07-24
Project End
2012-03-31
Budget Start
2009-04-01
Budget End
2010-03-31
Support Year
3
Fiscal Year
2009
Total Cost
$133,500
Indirect Cost
Name
University of Georgia
Department
Public Health & Prev Medicine
Type
Organized Research Units
DUNS #
004315578
City
Athens
State
GA
Country
United States
Zip Code
30602
Berenstein, Ariel José; Magariños, María Paula; Chernomoretz, Ariel et al. (2016) A Multilayer Network Approach for Guiding Drug Repositioning in Neglected Diseases. PLoS Negl Trop Dis 10:e0004300
Panunzi, Leonardo G; Agüero, Fernán (2014) A genome-wide analysis of genetic diversity in Trypanosoma cruzi intergenic regions. PLoS Negl Trop Dis 8:e2839
De Napoli, M G; de Miguel, N; Lebrun, M et al. (2013) N-terminal palmitoylation is required for Toxoplasma gondii HSP20 inner membrane complex localization. Biochim Biophys Acta 1833:1329-37
Laverriere, M; Cazzulo, J J; Alvarez, V E (2012) Antagonic activities of Trypanosoma cruzi metacaspases affect the balance between cell proliferation, death and differentiation. Cell Death Differ 19:1358-69
Buschiazzo, Alejandro; Muia, Romina; Larrieux, Nicole et al. (2012) Trypanosoma cruzi trans-sialidase in complex with a neutralizing antibody: structure/function studies towards the rational design of inhibitors. PLoS Pathog 8:e1002474
Li, Zhu-Hong; De Gaudenzi, Javier G; Alvarez, Vanina E et al. (2012) A 43-nucleotide U-rich element in 3'-untranslated region of large number of Trypanosoma cruzi transcripts is important for mRNA abundance in intracellular amastigotes. J Biol Chem 287:19058-69
Frasch, Alejandra P; Carmona, Adriana K; Juliano, Luiz et al. (2012) Characterization of the M32 metallocarboxypeptidase of Trypanosoma brucei: differences and similarities with its orthologue in Trypanosoma cruzi. Mol Biochem Parasitol 184:63-70
Magarinos, Maria P; Carmona, Santiago J; Crowther, Gregory J et al. (2012) TDR Targets: a chemogenomics resource for neglected diseases. Nucleic Acids Res 40:D1118-27
Avila, Maria L; Tekiel, Valeria; Moretti, Georgina et al. (2011) Gene discovery in Triatoma infestans. Parasit Vectors 4:39
Li, Zhu-Hong; Alvarez, Vanina E; De Gaudenzi, Javier G et al. (2011) Hyperosmotic stress induces aquaporin-dependent cell shrinkage, polyphosphate synthesis, amino acid accumulation, and global gene expression changes in Trypanosoma cruzi. J Biol Chem 286:43959-71

Showing the most recent 10 out of 19 publications