Our training program will focus on the genetics of schizophrenia (SZ) and bipolar I disorder (BPrincipal Investigator). Our training will occur primarily in India and Egypt, which have a combined population of over 1.2 billion. SZ and BPrincipal Investigator are common and substantial sources of morbidity world-wide, yet their treatment is unsatisfactory. SZ and BPrincipal Investigator may share etiological factors and manifest co-morbidity with several prevalent chronic disorders, such as obesity and coronary artery disease. All these diseases have a proven genetic etiology, with complex inheritance. Successful gene mapping efforts will require large samples. Such samples are difficult to ascertain in developed countries and are largely restricted to Caucasians. Such recruitment is more feasible in developing countries. Indeed, novel etiological factors may be present. Parallel studies in developing and developed countries may also clarify the role of genetic factors against diverse environmental backgrounds. Such research has lagged in developing countries. We have established productive psychiatric genetic studies at four collaborating sites in India, Egypt and at the University of Pittsburgh (PITT). Training / research infrastructure building have also been initiated. This proposal adds two more sites. We will continue training linked to ongoing research, each activity complementing the other. There are two components: (1) The primary component is doctoral (PhD) training for six candidates who will exploit and extend our rich dataset. The training will occur primarily at the overseas institutions, with complementary training at PITT. PITT faculty will actively supervise the trainees and train local faculty as needed. (2) We will organize three specialty training workshops and public symposia at the overseas sites. We will thus provide infrastructure development, extend our gene mapping efforts and facilitate interactive learning and problem solving among the tri-national collaborators. The present proposal will lay the groundwork for a tradition of collegial training and research in two large countries where psychiatric disorders are common, but are stigmatized.

Public Health Relevance

Treatment and research for schizophrenia and bipolar I disorder are important unmet needs in India and Egypt. We will continue training, infrastructure development and extend genetic epidemiological research already initiated by us. Thus we will enhance research in both psychiatry and genetics. The research will directly benefit the USA, by helping understand the pathogenesis of two common, severe, chronic, disabling disorders.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW008302-05
Application #
8531367
Study Section
Special Emphasis Panel (ZRG1-BDA-L (50))
Program Officer
Michels, Kathleen M
Project Start
2009-08-08
Project End
2014-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
5
Fiscal Year
2013
Total Cost
$103,591
Indirect Cost
$7,293
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Mansour, Hader; Tobar, Salwa; Fathi, Warda et al. (2015) Arabic versions of the sleep timing questionnaire and the composite scale of morningness. Asian J Psychiatr 13:48-51
Frank, E; Nimgaonkar, V L; Phillips, M L et al. (2015) All the world's a (clinical) stage: rethinking bipolar disorder from a longitudinal perspective. Mol Psychiatry 20:23-31
Kodavali, Chowdari V; Watson, Annie M; Prasad, Konasale M et al. (2014) HLA associations in schizophrenia: are we re-discovering the wheel? Am J Med Genet B Neuropsychiatr Genet 165:19-27
Bhatia, Triptish; Mazumdar, Sati; Mishra, Nagendra Narayan et al. (2014) Protocol to evaluate the impact of yoga supplementation on cognitive function in schizophrenia: a randomised controlled trial. Acta Neuropsychiatr 26:280-90
Bamne, Mikhil N; Ponder, Christine A; Wood, Joel A et al. (2013) Application of an ex vivo cellular model of circadian variation for bipolar disorder research: a proof of concept study. Bipolar Disord 15:694-700
Thomas, Pramod; Bhatia, Triptish; Gauba, Deepak et al. (2013) Exposure to herpes simplex virus, type 1 and reduced cognitive function. J Psychiatr Res 47:1680-5
Kukshal, Prachi; Kodavali, Venkat Chowdari; Srivastava, Vibhuti et al. (2013) Dopaminergic gene polymorphisms and cognitive function in a north Indian schizophrenia cohort. J Psychiatr Res 47:1615-22
Chowdari, Kodavali V; Bamne, Mikhil N; Nimgaonkar, Vishwajit L (2011) Genetic association studies of antioxidant pathway genes and schizophrenia. Antioxid Redox Signal 15:2037-45
Mansour, Hader; Fathi, Warda; Klei, Lambertus et al. (2010) Consanguinity and increased risk for schizophrenia in Egypt. Schizophr Res 120:108-12