The University of Chicago (UC) has supported active clinical and basic research programs as well as community-based research into the epidemiology and socio-cultural factors that contribute to disparities in the incidence and expression of breast cancer in partnership with the University of Ibadan (UI) and the University College Hospital (UCH) for more than a decade. The proposed International Partnership for Interdisciplinary Research Training in Chronic Non-Communicable Diseases and Disorders across the Lifespan program will deepen research methods skills amongst trainees in clinical research and introduce an important research methods dimension consistent with the needs expressed by in country collaborators. The dimension of interest is an interdisciplinary approach, a lateral shift, whereby trainees receive distinct added research training in another health related discipline such as bioethics, biostatistics, behavioral science, cancer biology, clinical pharmacology and pharmacogenetics, economics, demography, epidemiology, health policy, human genetics, immunology, molecular pathology, and the social sciences,. This lateral shift will increase capacity amongst trainees at various career levels to develop relevan hypotheses, plan appropriate study designs, operationalize research findings, nurture collaborations between investigators of different disciplines and in some trainees potentiate considerable shifts in thinking and approaches to preventing and curing the diseases that most affect this region and continent. Prototype trainees would be those who at the end of the program have deepened her/his primary research training in the clinical field they are most familiar with and has leveraged new health related discipline research methods OR one who has shifted to a primary focus on health related discipline with Masters or PhD level training and focusing on a given clinical topic; both with the goal of conducting team based interdisciplinary research that leads to substantive improvements in practical prevention and treatment practices. By consolidating and reorganizing existing research capacity within UI, strategic African-US teams will increasingly become fully operational and expand upon research projects to develop truly shared interdisciplinary programs. Program areas of focus have been selected by the joint Ibadan and Chicago training advisory group, and are particular areas where the UC can provide research support. The training program in Cancer is now fully operational having trained more than 200 Africans in the past ten years and now will advance to train a projected 416 Africans in 1) other non-communicable disorders such as Sickle Cell Disease, Asthma/COPD and Indoor Pollution as well as Women's Health; 2) expand to additional training methodologies and health disciplines such as dentistry, nursing and ophthalmology; 3) expand to other emerging South-South collaborations such as a new Nigeria-Tanzania partnership fostered by UC and 4) expand to other African countries through the African Organization on Research and Training In Cancer and African Society of Human Genetics.

Public Health Relevance

The University of Ibadan has the burden of history as the premier university in Nigeria to continue to provide leadership in the creation and deployment of knowledge for development. The proposed international partnership will allow Ibadan to realize its present vision of transforming into a postgraduate, research-driven university with focus on the development of translational research capacity and skills-set to meet the growing health needs of the country and the entire continent of Africa.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW009112-04
Application #
8826624
Study Section
Special Emphasis Panel ()
Program Officer
Michels, Kathleen M
Project Start
2012-07-12
Project End
2017-02-28
Budget Start
2015-03-01
Budget End
2016-02-29
Support Year
4
Fiscal Year
2015
Total Cost
$220,534
Indirect Cost
$10,757
Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Felix, Gabriela E S; Zheng, Yonglan; Olopade, Olufunmilayo I (2018) Mutations in context: implications of BRCA testing in diverse populations. Fam Cancer 17:471-483
Wang, Shengfeng; Ogundiran, Temidayo; Ademola, Adeyinka et al. (2018) Development of a Breast Cancer Risk Prediction Model for Women in Nigeria. Cancer Epidemiol Biomarkers Prev 27:636-643
Oluwasanu, Mojisola Morenike; Oladepo, Oladimeji (2017) Effects of a multi-level intervention on the pattern of physical activity among in-school adolescents in Oyo state Nigeria: a cluster randomised trial. BMC Public Health 17:833
Brown, Biobele J; Oladokun, Regina E; Ogunbosi, Babatunde O et al. (2017) Blood Transfusion-Associated HIV Infection in Children in Ibadan, Nigeria. J Int Assoc Provid AIDS Care 16:303-308
Michailidou, Kyriaki (see original citation for additional authors) (2017) Association analysis identifies 65 new breast cancer risk loci. Nature 551:92-94
Marquet, Sandrine; Conte, Ianina; Poudiougou, Belco et al. (2016) The IL17F and IL17RA Genetic Variants Increase Risk of Cerebral Malaria in Two African Populations. Infect Immun 84:590-7
Adetokunboh, Olatunji O; Oluwasanu, Mojisola (2016) Eliminating mother-to-child transmission of the human immunodeficiency virus in sub-Saharan Africa: The journey so far and what remains to be done. J Infect Public Health 9:396-407
Adedokun, Babatunde O; Olopade, Christopher O; Olopade, Olufunmilayo I (2016) Building local capacity for genomics research in Africa: recommendations from analysis of publications in Sub-Saharan Africa from 2004 to 2013. Glob Health Action 9:31026
Obilor, Helen N; Adejumo, Prisca O; Ilesanmi, Rose E (2016) Assessment of patients' wound-related pain experiences in University College Hospital, Ibadan, Nigeria. Int Wound J 13:697-704
Adedapo, Aduragbenro D A; Akunne, Onyinye O; Adedokun, Babatunde O (2015) Comparative assessment of determinants of health-related quality of life in hypertensive patients and normal population in south-west Nigeria. Int J Clin Pharmacol Ther 53:265-71

Showing the most recent 10 out of 74 publications