Nigeria has the second highest HIV burden and one of the highest rates of perinatal HIV transmission globally. HIV adversely affects the brain across the age spectrum (NeuroAIDS), causing a variety of derangements including neurocognitive, neurodevelopmental and neuropsychiatric disorders. These disorders worsen quality of life and drive poor adherence to antiretroviral treatment (ART), thereby increasing the risk of ART failure, morbidity, mortality, and HIV spread. Because relevant research has been neglected, there is no evidence-base to inform clinical practice locally and progress in the field has been limited. We have isolated the omissions in research infrastructure stunting emergence of a versatile NeuroAIDS research team and limiting NeuroAIDS research productivity despite over 20 years of dementia and related research at the University of Ibadan. We propose to capitalize on collaborations between diverse committed scientists and institutions, to address these omissions and develop sustainable NeuroAIDS research capacity at the University of Ibadan. Trainees in the proposed Multidisciplinary NeuroAIDS Research Training to Improve HIV Outcomes in Nigeria will acquire skills to address themes such as: i) impact of neurocognitive, neurodevelopmental and neuropsychiatric disorders on adherence, ART success, survival, and HIV spread across the age spectrum; ii) understanding the roles of aging, malnutrition and prevalent infections that may involve the central nervous system such as malaria and tuberculosis; and iii) discovering sustainable diagnostic, prevention and treatment strategies. Acquired skills will be relevant and broadly applicable to the NeuroAIDS field. Using structured mentoring, we will: 1) train and mentor neurologists/psychiatrists to have neuropsychological and neurodevelopmental expertise for NeuroAIDS research; 2) develop clinical research skills and provide didactic training to multidisciplinary investigators manifestig high potential to conduct NeuroAIDS research; 3) conduct short- and medium-term training practicums plus long-term mentoring to develop critical NeuroAIDS research skills in neuropharmacology, neuropsychological data analyses and grant writing; 4) conduct NeuroAIDS research symposia for researchers and intensive skills workshops for research support staff; and 5) establish a multidisciplinary NeuroAIDS research collaborative as an institutionally committed umbrella for sustainable multidisciplinary NeuroAIDS research. We will prepare a cadre of skilled, multidisciplinary researchers and outstanding research support staff, ensuring emergence of broad and integrative NeuroAIDS research expertise at the University of Ibadan. Trained scientists will contribute to discovery of sustainable solutions to NeuroAIDS, which will stimulate local health authorities to allocate more clinical and research resources to NeuroAIDS. A solid platform will emerge to support the next-level of grant applications such as the NIH Brain Disorders in Developing World: Research Across the Lifespan. Aggregated expertise will feed into University of Ibadan's long-term goal of developing a PhD Program in Neurosciences.

Public Health Relevance

We propose an HIV research training program at the University of Ibadan titled, 'Multidisciplinary NeuroAIDS Research Training to Improve HIV Outcomes in Nigeria.' Up to 50% of adults with AIDS have HIV Associated Neurocognitive Disorders (HAND) while neurodevelopmental disorders are pervasive in infected children and adolescents, worsening quality of life and driving HIV treatment failure, morbidity, mortality, and HIV spread. The proposed program will develop scientists who will lead discovery of sustainable solutions for NeuroAIDS in Nigeria and thereby amplify the benefits of HIV treatment for HIV infected individuals and society.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW009608-03
Application #
8811166
Study Section
Special Emphasis Panel ()
Program Officer
Mcdermott, Jeanne
Project Start
2013-08-05
Project End
2018-01-31
Budget Start
2015-02-01
Budget End
2016-01-31
Support Year
3
Fiscal Year
2015
Total Cost
$276,854
Indirect Cost
$11,681
Name
Northwestern University at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Adetunji, A A; Kuti, M A; Audu, R A et al. (2018) Discordant rapid HIV tests: lessons from a low-resource community. HIV Med 19:72-76
Leger, Paul; Chirwa, Sanika; Nwogu, Jacinta N et al. (2018) Race/ethnicity difference in the pharmacogenetics of bilirubin-related atazanavir discontinuation. Pharmacogenet Genomics 28:1-6
Adetunji, Adedotun A; Muyibi, Sufiyan A; Imhansoloeva, Martins et al. (2017) Mobile phone use for a social strategy to improve antiretroviral refill experience at a low-resource HIV clinic: patient responses from Nigeria. AIDS Care 29:575-578
Oladeji, Bibilola Damilola; Taiwo, Babafemi; Mosuro, Olushola et al. (2017) Suicidal Behavior and Associations with Quality of Life among HIV-Infected Patients in Ibadan, Nigeria. J Int Assoc Provid AIDS Care 16:376-382
Nwogu, Jacinta Nwamaka; Ma, Qing; Babalola, Chinedum Peace et al. (2016) Pharmacokinetic, Pharmacogenetic, and Other Factors Influencing CNS Penetration of Antiretrovirals. AIDS Res Treat 2016:2587094
Adejumo, Olurotimi; Oladeji, Bibilola; Akpa, Onoja et al. (2016) Psychiatric disorders and adherence to antiretroviral therapy among a population of HIV-infected adults in Nigeria. Int J STD AIDS 27:938-49
Adejumo, Olurotimi A; Malee, Kathleen M; Ryscavage, Patrick et al. (2015) Contemporary issues on the epidemiology and antiretroviral adherence of HIV-infected adolescents in sub-Saharan Africa: a narrative review. J Int AIDS Soc 18:20049