Half or more of HIV transmission events may occur within the period of high infectivity (and often high risk behavior) that can last 11 months or more after a person is initially infected. Unfortunately, neither test-and-treat intervention methods nor Acute HIV Infection projects have found effective ways to intervene against transmission during this risky """"""""recent infection"""""""" period. We seek to develop effective intervention techniques against HIV transmission among drug users and their community members during the recent infection period using a combination of drug injection-, sexual- and social-network-based contact tracing methods;community alerts in the networks and venues of recent infectees;and the logic of going """"""""up"""""""" and """"""""down"""""""" infection chains.
Our first Aim i s to develop and evaluate ways to locate """"""""seeds,"""""""" defined as drug users and other people who have recently been infected.
Our second Aim targets members of seeds' networks and people who attend their venues. We will test them for acute and for recent infection, and alert them to the probability that their networks contain highly-infectious members so they should reduce their risk and transmission behaviors for the next several months to minimize their chances of getting infected. This may also reduce transmission by untested people with recent infection. Community, network and venue education about the need and value of supporting those with recent infection should reduce stigma.
Our third Aim i s to reduce HIV transmission and to develop new ways to evaluate """"""""prevention for positives"""""""" generally as well as our own success in reducing transmission. We will do this using a combination of follow- up interviews and testing, including of viral loads;phylogenetic techniques;and discrete event simulation modeling to assess our effectiveness.
This project will attempt to develop an effective intervention to prevent HIV transmission by recently infected highly-infectious drug users and others during their first months of infectionwhich may account for 50% or more of all transmission events in some localities. The intervention will use up-to-date testing technologies and network tracing and intervention techniques to shorten infection chains and reduce HIV transmission rates. It will be tested in localities with new HIV epidemics and also among drug-using African American men who have sex with men, a group with high HIV incidence rates over the last decade or more.
|Williams, Leslie D; Kostaki, Evangelia-Georgia; Pavlitina, Eirini et al. (2018) Pockets of HIV Non-infection Within Highly-Infected Risk Networks in Athens, Greece. Front Microbiol 9:1825|
|Buchanan, Ashley L; Vermund, Sten H; Friedman, Samuel R et al. (2018) Assessing Individual and Disseminated Effects in Network-Randomized Studies. Am J Epidemiol 187:2449-2459|
|Paraskevis, Dimitrios; Nikolopoulos, Georgios K; Sypsa, Vana et al. (2018) Molecular investigation of HIV-1 cross-group transmissions during an outbreak among people who inject drugs (2011-2014) in Athens, Greece. Infect Genet Evol 62:11-16|
|Vasylyeva, Tetyana I; Liulchuk, Mariia; Friedman, Samuel R et al. (2018) Molecular epidemiology reveals the role of war in the spread of HIV in Ukraine. Proc Natl Acad Sci U S A 115:1051-1056|
|Magiorkinis, Gkikas; Karamitros, Timokratis; Vasylyeva, Tetyana I et al. (2018) An Innovative Study Design to Assess the Community Effect of Interventions to Mitigate HIV Epidemics Using Transmission-Chain Phylodynamics. Am J Epidemiol 187:2615-2622|
|Friedman, Samuel R; Williams, Leslie; Young, April M et al. (2018) Network Research Experiences in New York and Eastern Europe: Lessons for the Southern US in Understanding HIV Transmission Dynamics. Curr HIV/AIDS Rep 15:283-292|
|Smyrnov, Pavlo; Williams, Leslie D; Korobchuk, Ania et al. (2018) Risk network approaches to locating undiagnosed HIV cases in Odessa, Ukraine. J Int AIDS Soc 21:|
|Giannou, Foteini; Nikolopoulos, Georgios K; Pantavou, Katerina et al. (2017) Knowledge, Normative Beliefs and Attitudes Related to Recent HIV Infection among People who Inject Drugs in Athens, Greece. Curr HIV Res 15:386-395|
|Dombrowski, Kirk; Khan, Bilal; Habecker, Patrick et al. (2017) The Interaction of Risk Network Structures and Virus Natural History in the Non-spreading of HIV Among People Who Inject Drugs in the Early Stages of the Epidemic. AIDS Behav 21:1004-1015|
|Kostaki, Evangelia; Magiorkinis, Gkikas; Psichogiou, Mina et al. (2017) Detailed Molecular Surveillance of the HIV-1 Outbreak Among People who Inject Drugs (PWID) in Athens During a Period of Four Years. Curr HIV Res 15:396-404|
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