Eighty to ninety percent of what most young children learn about the world comes through vision. The same cannot be said when we seek to learn about the inner workings of our own body, because light beyond skin deep becomes diffused due to multiple scattering. Instead, researchers have resorted to alternative means-such as X-ray, magnetic resonance, and ultrasound-to probe deep into the body. Until now, most advances in optical imaging have been geared towards high-resolution functional and molecular imaging at depths less than 1 mm in scattering tissue. The pursuit of deep-tissue optical imaging with high spatial resolution has been stymied by the inherent optical diffusion-the grand challenge since the inception of biomedical optics. We must meet this challenge to reach the full potential of light because it is such a powerful tool from both the physical and biological perspectives. Physically, the tiny fraction of the electromagnetic spectrum that light covers is the only part that probes molecular structures directly; biologically, the ability of molecules to sense, react to, and emit light is encoded on the most fundamental (i.e., genetic) level! In addition, light as nonionizing radiation is as safe to biological organisms as air and water. Therefore, light is the most natural choice fo visualizing biological structures and events, interrogating and controlling biological processes, as well as diagnosing and treating diseases, if only we could overcome the optical diffusion-a seemingly unbreakable barrier. While multiple scattering of light is treated as a problem in conventional wisdom, I believe that it should be part of the solution. Our recent work on time-reversed ultrasonically encoded (TRUE) optical focusing (Nature Photonics 2011) is a first breakthrough in this direction. TRUE focusing can noninvasively deliver light to a dynamically defined focus deep in a scattering medium. This invention opens the door to an even greater paradigm-shifti

Public Health Relevance

Light as a form of noncarcinogenic radiation has important application in biomedicine for imaging, sensing, manipulation, and therapy. Delivering light deeply into scattering biological tissue has hindered such application. The proposed method for tunneling photons has the potential to fundamentally change the use of light in biomedicine. Public Health

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
NIH Director’s Pioneer Award (NDPA) (DP1)
Project #
7DP1EB016986-06
Application #
9421513
Study Section
Special Emphasis Panel (ZGM1-NDPA-A (01)X)
Program Officer
Shabestari, Behrouz
Project Start
2017-05-10
Project End
2017-07-31
Budget Start
2017-05-10
Budget End
2017-07-31
Support Year
6
Fiscal Year
2016
Total Cost
$825,000
Indirect Cost
$325,000
Name
California Institute of Technology
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
009584210
City
Pasadena
State
CA
Country
United States
Zip Code
91125
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Hemphill, Ashton S; Shen, Yuecheng; Liu, Yan et al. (2017) High-speed single-shot optical focusing through dynamic scattering media with full-phase wavefront shaping. Appl Phys Lett 111:221109
Li, Lei; Zhu, Liren; Ma, Cheng et al. (2017) Single-impulse Panoramic Photoacoustic Computed Tomography of Small-animal Whole-body Dynamics at High Spatiotemporal Resolution. Nat Biomed Eng 1:
Yang, Jiamiao; Gong, Lei; Xu, Xiao et al. (2017) Motionless volumetric photoacoustic microscopy with spatially invariant resolution. Nat Commun 8:780
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Wong, Terence T W; Zhang, Ruiying; Zhang, Chi et al. (2017) Label-free automated three-dimensional imaging of whole organs by microtomy-assisted photoacoustic microscopy. Nat Commun 8:1386
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Shen, Yuecheng; Liu, Yan; Ma, Cheng et al. (2017) Sub-Nyquist sampling boosts targeted light transport through opaque scattering media. Optica 4:97-102
Wong, Terence T W; Zhou, Yong; Garcia-Uribe, Alejandro et al. (2017) Use of a single xenon flash lamp for photoacoustic computed tomography of multiple-centimeter-thick biological tissue ex vivo and a whole mouse body in vivo. J Biomed Opt 22:41003

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