There are a large range of diseases and therapies of the heart that can benefit from the information provided by a high-resolution, real time imaging modality. Diseases and abnormalities of the myocardium are due to problems of the heart muscle, ranging from infections to abnormalities in conduction, structure, and contraction. For these conditions, catheters are inserted into the heart chambers, without a direct view of the heart wall to obtain electrical measurements, take biopsies to detect cellular changes, or delivery energy to treat arrhythmias. It is our goal to develop tools for imaging the myocardium, which will provide cardiac electrophysiologist, cardiologist, and heart surgeons a view of the heart wall to aid in disease diagnosis and guide therapy. Our objective is to develop high-resolution optical imaging modalities and image analysis for diagnosis and therapy monitoring of diseases of the heart wall. Applications of optical imaging in the myocardium range from assessment of transplant rejection by preforming an optical biopsy to monitoring radiofrequency ablation therapy. This DP2 New Innovator proposal focuses on establishing a platform imaging modality including designing optical catheters and developing classification algorithms for real time imaging of the myocardium in the cardiovascular and cardiac electrophysiology laboratory.
We aim to demonstrate that OCT can address unmet clinical needs of cardiac imaging by providing cellular-level imaging of the myocardium. Our approach is multi-scaled including: developing high resolution OCT system with and without polarization sensitivity optimized for myocardial imaging, and prototyping high resolution catheters to perform optical biopsy and provide three dimensional imaging of myocardial substrates. We will evaluate the new technology developed on human myocardial tissue ex vivo with and without the presence of blood.
Diseases and abnormalities of the myocardium are due to problems of the heart muscle, ranging from infections to abnormalities in conduction, structure, and contraction. For these conditions, catheters are inserted into the heart chambers, without a direct view of the heart wall to obtain electrical measurements, take biopsies to detect cellular changes, or delivery energy to treat arrhythmias. Real time imaging at the cellular level will provide additional insights into myocardial remodeling to aid disease diagnosis and target therapeutic interventions.
|Ling, Yuye; Yao, Xinwen; Gamm, Ute A et al. (2017) Ex vivo visualization of human ciliated epithelium and quantitative analysis of induced flow dynamics by using optical coherence tomography. Lasers Surg Med 49:270-279|
|Yao, Xinwen; Gan, Yu; Chang, Ernest et al. (2017) Visualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT. Lasers Surg Med 49:258-269|
|Ling, Yuye; Gan, Yu; Yao, Xinwen et al. (2017) Phase-noise analysis of swept-source optical coherence tomography systems. Opt Lett 42:1333-1336|
|Yu Gan; Xinwen Yao; Chang, Ernest et al. (2016) Comparative study of texture features in OCT images at different scales for human breast tissue classification. Conf Proc IEEE Eng Med Biol Soc 2016:3926-3929|
|Yao, Xinwen; Gan, Yu; Marboe, Charles C et al. (2016) Myocardial imaging using ultrahigh-resolution spectral domain optical coherence tomography. J Biomed Opt 21:61006|
|Gan, Yu; Tsay, David; Amir, Syed B et al. (2016) Automated classification of optical coherence tomography images of human atrial tissue. J Biomed Opt 21:101407|
|Yao, Wang; Gan, Yu; Myers, Kristin M et al. (2016) Collagen Fiber Orientation and Dispersion in the Upper Cervix of Non-Pregnant and Pregnant Women. PLoS One 11:e0166709|
|Gan, Yu; Yao, Wang; Myers, Kristin M et al. (2015) Analyzing three-dimensional ultrastructure of human cervical tissue using optical coherence tomography. Biomed Opt Express 6:1090-108|
|Myers, Kristin M; Hendon, Christine P; Gan, Yu et al. (2015) A continuous fiber distribution material model for human cervical tissue. J Biomech 48:1533-40|
|Singh-Moon, Rajinder P; Marboe, Charles C; Hendon, Christine P (2015) Near-infrared spectroscopy integrated catheter for characterization of myocardial tissues: preliminary demonstrations to radiofrequency ablation therapy for atrial fibrillation. Biomed Opt Express 6:2494-511|
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