Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
NIH Director’s New Innovator Awards (DP2)
Project #
1DP2OD001315-01
Application #
7426966
Study Section
Special Emphasis Panel (ZGM1-NDIA-G (07))
Program Officer
Basavappa, Ravi
Project Start
2007-09-30
Project End
2012-08-31
Budget Start
2007-09-30
Budget End
2012-08-31
Support Year
1
Fiscal Year
2007
Total Cost
$2,370,000
Indirect Cost
Name
Princeton University
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
002484665
City
Princeton
State
NJ
Country
United States
Zip Code
08544
Lee, Andrew H; Dhingra, Satish K; Lewis, Ian A et al. (2018) Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter. Sci Rep 8:13578
Mancio-Silva, Liliana; Slavic, Ksenija; Grilo Ruivo, Margarida T et al. (2017) Nutrient sensing modulates malaria parasite virulence. Nature 547:213-216
Painter, Heather J; Carrasquilla, Manuela; Llinás, Manuel (2017) Capturing in vivo RNA transcriptional dynamics from the malaria parasite Plasmodium falciparum. Genome Res 27:1074-1086
Cobbold, Simon A; Llinás, Manuel; Kirk, Kiaran (2016) Sequestration and metabolism of host cell arginine by the intraerythrocytic malaria parasite Plasmodium falciparum. Cell Microbiol 18:820-30
Cobbold, Simon A; Santos, Joana M; Ochoa, Alejandro et al. (2016) Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite. Sci Rep 6:19722
Adjalley, Sophie H; Scanfeld, Daniel; Kozlowski, Elyse et al. (2015) Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1. BMC Genomics 16:1090
Ke, Hangjun; Lewis, Ian A; Morrisey, Joanne M et al. (2015) Genetic investigation of tricarboxylic acid metabolism during the Plasmodium falciparum life cycle. Cell Rep 11:164-74
Lisewski, Andreas Martin; Quiros, Joel P; Ng, Caroline L et al. (2014) Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate. Cell 158:916-928
Lewis, Ian A; Wacker, Mark; Olszewski, Kellen L et al. (2014) Metabolic QTL analysis links chloroquine resistance in Plasmodium falciparum to impaired hemoglobin catabolism. PLoS Genet 10:e1004085
O'Hara, Jessica K; Kerwin, Lewis J; Cobbold, Simon A et al. (2014) Targeting NAD+ metabolism in the human malaria parasite Plasmodium falciparum. PLoS One 9:e94061

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