The goals for this fellowship are to develop and test the application of compartmental models to describe lipoprotein tracer data. This fellowship will focus on two problems. The first being the development of a compartmental model to describe the kinetics of apolipoprotein B (apoB) and triglyceride within the VLDL, IDL and LDL fractions of individuals with visceral obesity on eicosapentanoic acid and Atorvastatin (an HMGCoA reductase inhibitor) therapy. The novelty of this study involves the simultaneous use of tracers for the apoB and triglyceride moieties of the lipoprotein particles. The second problem will involve the development and testing of a compartmental model of chylomicron remnant metabolism using a breath test. Previous studies have used the Vitamin A protocol, the results of which are difficult to analyze. The goal of this project is to develop a model which will describe the rates of remnant catabolism following the infusion of labeled fatty acids.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Unknown (F06)
Project #
1F06TW002272-01
Application #
2520134
Study Section
Special Emphasis Panel (ZRG2-GMA-2 (01))
Project Start
1999-01-29
Project End
Budget Start
1998-02-01
Budget End
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Washington
Department
Engineering (All Types)
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195