Swallowing is a well-coordinated activity regulated by the hyolaryngeal muscles and at least five cranial nerves. Swallowing disorders, or dysphagia, can impact nutrition and quality of life for infants. The proposed study aims to further the understand sensory motor integration between the oral phase and pharyngeal phase of the infant swallow. I will use an infant pig model to study the impact of locally anesthetizing palatal and perioral sensory nerves on swallowing kinematics and motor response. I hypothesize that this oral sensory deficit will result in decreased airway protection during swallowing. I will recod feeding with simultaneous videofluroscopy and EMG recording for local anesthetic and saline treatments to both the perioral and palatal regions and compare them to controls to determine the effect of oral sensation on the pharyngeal swallow. Understanding the mechanism by which oral sensory information regulates hyolaryngeal muscle function will be important for developing techniques to rehabilitate infants with dysphagia. The findings of the proposed study could lead to new devices that are maximally effective for dysphagia rehabilitation.

Public Health Relevance

Normal swallowing and feeding is necessary for health and quality of life. The aim of this proposal is to understand the role of oral sensation during sucklig and swallowing. If oral sensory afferents affect suckling and swallowing ability, then stimulating the oral region may be used as a component of dysphagia rehabilitation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Individual Predoctoral NRSA for M.D./Ph.D. Fellowships (ADAMHA) (F30)
Project #
5F30DE021944-02
Application #
8534452
Study Section
NIDCR Special Grants Review Committee (DSR)
Program Officer
Frieden, Leslie A
Project Start
2013-02-01
Project End
2015-03-31
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
2
Fiscal Year
2014
Total Cost
$48,032
Indirect Cost
Name
University of Maryland Baltimore
Department
Other Basic Sciences
Type
Schools of Dentistry
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Ding, Peng; Fung, George Shiu-Kai; Lin, MingDe et al. (2015) The effect of bilateral superior laryngeal nerve lesion on swallowing: a novel method to quantitate aspirated volume and pharyngeal threshold in videofluoroscopy. Dysphagia 30:47-56
Holman, Shaina D; Campbell-Malone, Regina; Ding, Peng et al. (2014) Swallowing kinematics and airway protection after palatal local anesthesia in infant pigs. Laryngoscope 124:436-45
Holman, Shaina Devi; Gierbolini-Norat, Estela M; Lukasik, Stacey L et al. (2014) Duration of action of bupivacaine hydrochloride used for palatal sensory nerve block in infant pigs. J Vet Dent 31:92-5
Gierbolini-Norat, Estela M; Holman, Shaina D; Ding, Peng et al. (2014) Variation in the timing and frequency of sucking and swallowing over an entire feeding session in the infant pig Sus scrofa. Dysphagia 29:475-82
Holman, Shaina Devi; Waranch, Danielle R; Campbell-Malone, Regina et al. (2013) Sucking and swallowing rates after palatal anesthesia: an electromyographic study in infant pigs. J Neurophysiol 110:387-96