Long-Term Objectives: The primary goal of this proposal is to use a lifespan perspective to examine how genetic and environmental factors influence, and interact to influence, problematic alcohol involvement, personality, and drinking motives. Ultimately, the goal of this project is to provide further information on how genes and environment contribute to alcohol involvement, personality, and motives, and to what extent genes and environment explain the relations among these constructs.
Specific Aims : The primary aims of this proposal are to prospectively examine measured gene-environment correlations and interactions that contribute to personality constructs as well as drinking motives related to problematic alcohol involvement, and to further determine the extent to which measured gene-environment correlations and interactions contributing to personality and drinking motives account for the relation of these factors with problematic alcohol involvement. These analyses will be conducted in two, multiwave datasets that include genotypic data. Significance: The results from this project could provide information towards improved approaches for identifying, treating, and preventing alcohol use disorders and could clarify how gene-environment correlations and interactions influence alcohol relevant personality, motives, and behaviors.

Public Health Relevance

Relevance Briefly, the proposed research project can help researchers and clinicians better understand how genetic risk interacts with environmental exposures to influence personality and drinking motives related to alcohol problems. This information can be used to design treatments that consider individual differences in genetic risk as well as environmental factors in order to better address problem drinking.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31AA019596-03
Application #
8249526
Study Section
Health Services Research Review Subcommittee (AA)
Program Officer
Parsian, Abbas
Project Start
2010-04-09
Project End
2012-07-08
Budget Start
2012-04-10
Budget End
2012-07-08
Support Year
3
Fiscal Year
2012
Total Cost
$8,860
Indirect Cost
Name
University of Missouri-Columbia
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
153890272
City
Columbia
State
MO
Country
United States
Zip Code
65211
Haeny, Angela M; Littlefield, Andrew K; Sher, Kenneth J (2014) Repeated diagnoses of lifetime alcohol use disorders in a prospective study: insights into the extent and nature of the reliability and validity problem. Alcohol Clin Exp Res 38:489-500
Haeny, Angela M; Littlefield, Andrew K; Sher, Kenneth J (2014) False negatives in the assessment of lifetime alcohol use disorders: a serious but unappreciated problem. J Stud Alcohol Drugs 75:530-5
Ellingson, Jarrod M; Verges, Alvaro; Littlefield, Andrew K et al. (2013) Are bottom-up and top-down traits in dual-systems models of risky behavior genetically distinct? Behav Genet 43:480-90
Cadigan, Jennifer M; Littlefield, Andrew K; Martens, Matthew P et al. (2013) Transitions into and out of intercollegiate athletic involvement and risky drinking. J Stud Alcohol Drugs 74:21-9
Littlefield, Andrew K; Vergés, Alvaro; Rosinski, Jenny M et al. (2013) Motivational typologies of drinkers: do enhancement and coping drinkers form two distinct groups? Addiction 108:497-503
Littlefield, Andrew K; Sher, Kenneth J (2012) Smoking desistance and personality change in emerging and young adulthood. Nicotine Tob Res 14:338-42
Littlefield, Andrew K; Talley, Amelia E; Jackson, Kristina M (2012) Coping motives, negative moods, and time-to-drink: exploring alternative analytic models of coping motives as a moderator of daily mood-drinking covariation. Addict Behav 37:1371-6
Agrawal, Arpana; Nelson, Elliot C; Littlefield, Andrew K et al. (2012) Cannabinoid receptor genotype moderation of the effects of childhood physical abuse on anhedonia and depression. Arch Gen Psychiatry 69:732-40
Bailey, Drew H; Littlefield, Andrew; Geary, David C (2012) The codevelopment of skill at and preference for use of retrieval-based processes for solving addition problems: individual and sex differences from first to sixth grades. J Exp Child Psychol 113:78-92
Littlefield, Andrew K; Vergés, Alvaro; Wood, Phillip K et al. (2012) Transactional models between personality and alcohol involvement: a further examination. J Abnorm Psychol 121:778-83

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