Both animal and human models of alcoholism etiology have focused on biobehavioral response to alcohol as a potential marker of alcoholism risk vulnerability and disease progression. Alcoholism has been conceptualized in neurobiological models as a transition from positive reinforcement (i.e., """"""""drinking to feel good"""""""") to negative reinforcement (i.e., """"""""drinking not to feel bad or to feel normal""""""""), representing a cycl of progressive neurobiological dysregulation. Alcohol administration studies in the human laboratory allow for the translation of preclinical theory to clinical populations through examination of the subjective response to alcohol (comprising stimulation, sedation and tension relieving dimensions) at different levels of drinking status (i.e. heavy drinking or alcohol dependent groups). To date, no studies have used alcohol administration paradigms to translate neurobiological models of alcoholism etiology to clinical populations. The objective of this NRSA application is to foster my development as a clinical neuroscientist focusing on alcoholism through the investigation of well-established neurobiological theories of alcoholism etiology in the human laboratory. To do so, this study combines traditional alcohol challenge and progressive ratio self-administration methodologies to elucidate the relationship between subjective response to alcohol and one's willingness to work for alcohol. In order to model the transition from positively to negatively reinforced alcohol use, two groups (ntotal = 82) will be recruited, a group of non-dependent heavy drinkers and a group of alcohol dependent individuals. The present study extends the alcoholism literature through testing neurobiologically informed hypotheses about the moderating role of drinking status on subjective response to alcohol in the lab and the relationship between subjective response and self-administration of additional alcohol ad lib.

Public Health Relevance

Alcoholism is a debilitating and costly psychiatric disorder whose neurobiological underpinnings remain poorly understood. Neurobiological models have garnered considerable evidence in preclinical research but have yet to be translated to clinical samples with alcoholism. The proposed research testing neurobiologically-driven hypotheses about subjective response to alcohol and alcohol self-administration in the lab seeks to advance our understanding of alcoholism etiology and maintenance.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Predoctoral Individual National Research Service Award (F31)
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Biomedical Research Review Subcommittee (AA)
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Urbanas, Diana
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University of California Los Angeles
Schools of Arts and Sciences
Los Angeles
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Ray, Lara A; Bujarski, Spencer; Roche, Daniel J O (2016) Subjective Response to Alcohol as a Research Domain Criterion. Alcohol Clin Exp Res 40:6-17
Bujarski, Spencer; Ray, Lara A (2016) Experimental psychopathology paradigms for alcohol use disorders: Applications for translational research. Behav Res Ther 86:11-22
Bujarski, Spencer; Roche, Daniel J O; Sheets, Erin S et al. (2015) Modeling naturalistic craving, withdrawal, and affect during early nicotine abstinence: A pilot ecological momentary assessment study. Exp Clin Psychopharmacol 23:81-9
Sheets, Erin S; Bujarski, Spencer; Leventhal, Adam M et al. (2015) Emotion differentiation and intensity during acute tobacco abstinence: A comparison of heavy and light smokers. Addict Behav 47:70-3
Ray, Lara A; Bujarski, Spencer; Courtney, Kelly E et al. (2015) The Effects of Naltrexone on Subjective Response to Methamphetamine in a Clinical Sample: a Double-Blind, Placebo-Controlled Laboratory Study. Neuropsychopharmacology 40:2347-56
Bujarski, Spencer; Hutchison, Kent E; Roche, Daniel J O et al. (2015) Factor Structure of Subjective Responses to Alcohol in Light and Heavy Drinkers. Alcohol Clin Exp Res 39:1193-202
Bujarski, Spencer; Ray, Lara A (2014) Subjective response to alcohol and associated craving in heavy drinkers vs. alcohol dependents: an examination of Koob's allostatic model in humans. Drug Alcohol Depend 140:161-7
Bujarski, Spencer; Roche, Daniel J O; Lunny, Katy et al. (2014) The relationship between methamphetamine and alcohol use in a community sample of methamphetamine users. Drug Alcohol Depend 142:127-32