This proposal describes a 5-year training program for completing the graduate program in Immunology at Stanford University. The principal investigator is an MD/PhD student, who has completed the first two years of medical school and is beginning his graduate studies. Stanford University combines strengths in both basic science and clinical research, especially as it pertains to the molecular basis of immunology, and thus will be fertile environment for developing my career in academic medicine. My proposal focuses on molecular aspects of macrophage activation, especially as it relates to signaling by nuclear hormone receptors, PPAR gamma and delta. Previous studies by various laboratories have identified these transcription factors as key regulators of macrophage lipid metabolism, inflammatory response and atherosclerosis. However, the molecular programs by which these receptors control macrophage biology and activation remain poorly understood. The studies proposed in the present grant application will take biochemical, molecular, and genetic approaches to further investigate how PPAR gamma and delta orchestrate the macrophage response to incoming fatty acids.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31AI066402-02
Application #
7083600
Study Section
Special Emphasis Panel (ZRG1-IDM-P (29))
Program Officer
Hernandez, Milton J
Project Start
2005-09-30
Project End
2009-09-29
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
2
Fiscal Year
2006
Total Cost
$43,157
Indirect Cost
Name
Stanford University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Ricardo-Gonzalez, Roberto R; Red Eagle, Alex; Odegaard, Justin I et al. (2010) IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity. Proc Natl Acad Sci U S A 107:22617-22
Mukundan, Lata; Odegaard, Justin I; Morel, Christine R et al. (2009) PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance. Nat Med 15:1266-72
Odegaard, Justin I; Ricardo-Gonzalez, Roberto R; Red Eagle, Alex et al. (2008) Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab 7:496-507