Photomagnetic Imaging: A Novel Modality for Cancer Imaging In the last decades, variety of in vivo imaging modalities have been developed using a broad spectrum of technologies to obtain structural, functional, and molecular information about the tissue under investigation. As one of these modalities, optical imaging can provide functional information such as hemoglobin concentration and also visualize exogenous contrast agents as well as molecular and functional markers. Unfortunately, optical imaging suffers from low resolution due to highly scattering nature of the biological tissue. Although, there are new emerging modalities like photo-acoustic tomography that can provide higher resolution images, quantitative accuracy of the recovered parameters still remains as one of the main issues. One common weakness of all these available optical imaging techniques is that they are capable of acquiring data only from the boundary of the medium. To overcome this limitation, my main goal in this proposal is to develop an entirely new approach, "Photo-magnetic imaging", which still uses laser light to heat the medium under investigation but employ MRI to obtain the temperature map of the tissue with high resolution. The MR temperature maps will further be converted into the optical absorption maps using proper modeling of light propagation and heat transfer in tissue. My hypothesis is that the photo-magnetic imaging technique will provide quantitatively more accurate and higher resolution images due to acquisition of data from the whole medium under investigation that improves the underdetermined condition of the inverse problem. This training proposal is geared toward the first in vivo feasibility studies of this nove imaging modality using small animals. If successful, the outcome will be the beginning of a new imaging modality. Due to the utilization of a clinical MR scanner, this technique will have immediate clinical translation potential.

Public Health Relevance

Photomagnetic Imaging: A Novel Modality for Cancer Imaging This is a training grant that focuses on development of a new bio-medical imaging modality termed Photo-Magnetic Imaging (PMI). Optical imaging can provide tissue functional information such as hemoglobin concentration and also visualize exogenous contrast agents. Indeed, in vivo optical imaging extends across a wide range of applications, from cellular to organ levels. Unfortunately, optical imaging suffers from low resolution due to the highly scattering nature of the biological tissue. Although, there are new emerging modalities like photo-acoustic tomography that can provide higher resolution images, quantitative accuracy of the recovered parameters still remains as one of the main issues. This application is aiming for developing an entirely new approach, Photo-magnetic Imaging, which still uses laser light to heat the medium under investigation but employ MRI to obtain the temperature map of the tissue with high resolution. The ultimate aim for this training program is to get high resolution and quantitatively correct optical images of the tissue using MR temperature measurements.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31CA171745-01A1
Application #
8458007
Study Section
Special Emphasis Panel (ZRG1-F15-P (20))
Program Officer
Korczak, Jeannette F
Project Start
2013-03-14
Project End
2016-03-13
Budget Start
2013-03-14
Budget End
2014-03-13
Support Year
1
Fiscal Year
2013
Total Cost
$42,232
Indirect Cost
Name
University of California Irvine
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Nouizi, Farouk; Luk, Alex; Thayer, Dave et al. (2016) Experimental validation of a high-resolution diffuse optical imaging modality: photomagnetic imaging. J Biomed Opt 21:16009
Nouizi, F; Erkol, H; Luk, A et al. (2016) An accelerated photo-magnetic imaging reconstruction algorithm based on an analytical forward solution and a fast Jacobian assembly method. Phys Med Biol 61:7448-7465
Erkol, H; Nouizi, F; Unlu, M B et al. (2015) An extended analytical approach for diffuse optical imaging. Phys Med Biol 60:5103-21
Erkol, Hakan; Nouizi, Farouk; Luk, Alex et al. (2015) Comprehensive analytical model for CW laser induced heat in turbid media. Opt Express 23:31069-84
Luk, Alex T; Ha, Seunghoon; Nouizi, Farouk et al. (2014) A True Multi-modality Approach for High Resolution Optical Imaging: Photo-Magnetic Imaging. Proc SPIE Int Soc Opt Eng 8937:
Lin, Yuting; Gao, Hao; Thayer, David et al. (2013) Photo-magnetic imaging: resolving optical contrast at MRI resolution. Phys Med Biol 58:3551-62