? Research on adult motivational profiles for substance use suggests that temperamental differences influence an individual's incentive for using drugs and alcohol. For example, adults who score high on sensation seeking are likely to abuse alcohol for its reward properties, whereas adults who score high on trait anxiety are likely to abuse alcohol for its anxiolytic effects. Although responses to alcohol cannot be measured directly in children, temperamentally based responses to reward and anxiety-inducing stimuli can be assessed through physiological measures collected during other incentive and aversive conditions. Psychophysiological measures that have proven useful in assessing temperamental traits include cardiac pre-ejection period (PEP), electrodermal responding (EDR), and respiratory sinus arrhythmia (RSA). Under appropriate stimulus conditions, PEP, EDR, and RSA can be used to index reward insensitivity, trait anxiety, and emotion dysregulation, respectively. Measuring PEP, EDR, and RSA will allow for physiological assessment of motivation and emotion regulation while children respond to reward and punishment. This will allow for the examination of the relations between reward insensitivity, trait anxiety, emotion dysregulation and the initiation and escalation of substance use in pre-adolescents with depression and conduct disorder. In addition, the interaction of both self report and physiological measures of temperament with social risk factors including coercive parenting, parental monitoring, and school bonding will be examined. ? ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31DA019765-03
Application #
7436335
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Etz, Kathleen
Project Start
2006-06-01
Project End
2008-06-30
Budget Start
2008-06-01
Budget End
2008-06-30
Support Year
3
Fiscal Year
2008
Total Cost
$13,173
Indirect Cost
Name
University of Washington
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195