The sense of smell permits animals to find food, recognize mates, and avoid predators. It is possible to study this complex sensory modality at the level of olfactory genes, neurons, and circuits in the powerful genetic model organism, the Drosophila fruit fly. In both mammals and insects, olfactory neurons have evolved to detect odors associated with food. Complex neural circuitry must be brought to bear upon the problem of discriminating attractants in high quality food from repellents that might signify food tainted by spoilage. Drosophila has two olfactory sensory organs, the antenna and maxillary palp, but the relative role of these two structures in general food odor detection is poorly understood. The proposed experiments will address the possible role of the maxillary palp in detecting specific repellents. Genetic mapping experiments will be performed to elucidate the wiring logic of the maxillary palp as it innervates the first olfactory relay in the brain. Using a behavioral genetic approach, we will define the role of identified maxillary palp neurons in detecting and mediating avoidance of certain repellent stimuli. The results will increase understanding of the neural circuitry that underlies stereotyped feeding behaviors important in all species.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31DC006795-02
Application #
6882031
Study Section
Communication Disorders Review Committee (CDRC)
Program Officer
Sklare, Dan
Project Start
2004-04-01
Project End
2007-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
2
Fiscal Year
2005
Total Cost
$47,470
Indirect Cost
Name
Rockefeller University
Department
Anatomy/Cell Biology
Type
Other Domestic Higher Education
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
Fishilevich, Elane; Domingos, Ana I; Asahina, Kenta et al. (2005) Chemotaxis behavior mediated by single larval olfactory neurons in Drosophila. Curr Biol 15:2086-96
Fishilevich, Elane; Vosshall, Leslie B (2005) Genetic and functional subdivision of the Drosophila antennal lobe. Curr Biol 15:1548-53