The applicant will investigate the biochemical role of the cbiB protein in de novo coenzyme B12 synthesis. This work is needed to fill an important gap of knowledge of this major biosynthetic pathway. This work will have important implications on our understanding of how precursors available in the cells environment are salvaged and converted into coenzyme B12. A combination of in vivo genetics, molecular biological biochemical, and crystallographic approaches will be employed to dissect how this important enzyme works.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31GM064009-02
Application #
6696413
Study Section
Special Emphasis Panel (ZRG1-BIOL-1 (01))
Program Officer
Gaillard, Shawn R
Project Start
2001-12-01
Project End
Budget Start
2002-12-01
Budget End
2003-11-30
Support Year
2
Fiscal Year
2003
Total Cost
$38,606
Indirect Cost
Name
University of Wisconsin Madison
Department
Microbiology/Immun/Virology
Type
Schools of Earth Sciences/Natur
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715