Habituation-defined as the decrease in response to the same information over time-is a fundamental process by which we learn about the environment around us. Humans must continually process vast amounts of incoming sensory information. Habituation is thought to play a role in filtering incoming information. As an individual learns that a stimulus in the environment is neither threatening nor rewarding, the stimulus becomes safe and familiar, resulting in habituation at both the behavioral and neural levels. However, failure to habituate to non-threatening stimuli in the environment may trigger feelings of uncertainty or unfamiliarity, resulting in fear and anxiety. Evidence in shy individual supports the hypothesis that habituation may be related to increased social fearfulness. For example, shy individuals are typically slow to acclimate to new people and objects, consistent with slower habituation. Additionally, our lab has recently shown that shy individuals fail to show habituation to novel faces in the amygdala and hippocampus, two brain regions associated with fear and evaluation of threat. However, no studies to date have been conducted exploring habituation in individuals ranging from low to high in social fearfulness. Because individual differences in habituation to social stimuli may provide an important neurobiological marker for risk for psychiatric illness, such as social phobia, we propose that exploration of habituation in individuals ranging from low to high in social fearfulness is critical. In order to study how the rte of habituation contributes to social fearfulness, we will recruit a group of individuals that range from low to high social fearfulness. Using functional MRI, we will measure neural habituation to repeated presentations of neutral human faces. We hypothesize that social fearfulness will be inversely correlated with habituation;individuals with higher levels of social fearfulness will fal to show habituation in several key brain regions that are involved in the expression of fear, including the amygdala, the hippocampus, the ventral and medial prefrontal cortex, and the fusiform face area. However, brain regions do not work in isolation;rather, processing of potential threats occurs over many brain regions that comprise a complex functional network. Therefore, we will also explore functional connectivity across each of these brain regions. As each of these key threat processing brain regions are both structurally and functionally connected, we hypothesize that habituation patterns will be reflected across regions within this network. Specifically, we hypothesize that prolonged communication (failure to habituate) between regions when viewing faces will be associated with higher levels of social fearfulness.

Public Health Relevance

Although preliminary evidence has associated abnormal habituation in some brain regions with high levels of social fearfulness, little is known about how individual differences in habituation contribute to individual differences in social fear;therefor, this study will characterize the association between neural habituation and individual differences in social fearfulness. The results of this project will advance our knowledge about how the timecourse of brain activity leads to social fearfulness and anxiety. This new knowledge has the potential to guide individual treatment selection, identify individuals at highest risk for developng social anxiety, and serve as a marker of treatment efficacy.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Predoctoral Individual National Research Service Award (F31)
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Special Emphasis Panel (ZRG1-F02A-J (20))
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Rosemond, Erica K
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Vanderbilt University Medical Center
Schools of Medicine
United States
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Avery, S N; Clauss, J A; Blackford, J U (2016) The Human BNST: Functional Role in Anxiety and Addiction. Neuropsychopharmacology 41:126-41
Avery, Suzanne N; VanDerKlok, Ross M; Heckers, Stephan et al. (2016) Impaired face recognition is associated with social inhibition. Psychiatry Res 236:53-7
Avery, Suzanne N; Blackford, Jennifer Urbano (2016) Slow to warm up: the role of habituation in social fear. Soc Cogn Affect Neurosci 11:1832-1840
Clauss, J A; Avery, S N; Blackford, J U (2015) The nature of individual differences in inhibited temperament and risk for psychiatric disease: A review and meta-analysis. Prog Neurobiol 127-128:23-45
Blackford, Jennifer Urbano; Clauss, Jacqueline A; Avery, Suzanne N et al. (2014) Amygdala-cingulate intrinsic connectivity is associated with degree of social inhibition. Biol Psychol 99:15-25