This research project concerns the correlations between brain energy metabolism determined by PET and resting EEG measured simultaneously in both normal and depressed human subjects. It is a subproject in the research program of Dr. Richard Davidson of th Dept. of Psychology; my sponsor, Dr. James Holden of th Depts. of Medical Physics and Radiology, is collaborator and co-investigator in the imaging projects of that program. Modeling of the anatomical and physiological effects that link the two modalities will be performed. Three primary effects will be studied. MRI data will be used to study t he anatomical effects on EEG on EEG scalp potentials that confound the relationship between scalp potentials and cortical activity. Temporal weighting techniques based on data from the PET measurements will be developed to weight the EEG data acquired over extended time periods so that the electrical and metabolic data reflect the brain activity time course in similar ways. Finally, models of source generator distributions will be studied and used to determine optimal spatial regions of interest for the spatial averaging of the metabolic data to be correlated with the EEG data. Data processed using the methods developed will be used in several statistical correlation studies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31NS010205-04
Application #
2891516
Study Section
Special Emphasis Panel (ZRG4-GRM (03))
Program Officer
Jacobs, Tom P
Project Start
1999-08-01
Project End
Budget Start
1999-08-01
Budget End
2000-07-31
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Physics
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715