One of the most common treatments for patients with hydrocephalus is the surgical implantation of a cerebrospinal-fluid (CSF) shunt. Unfortunately, this device, which is critical for managing hydrocephalus, has a substantial failure rate. The goal of this project is to reduce the frequency of catheter replacement surgeries or to eliminate them all together. I propose to accomplish this by designing a ventricular catheter that will resist occlusion due to cellular accumulation, through the use of micromachining and biological micro-electro-mechanical systems (bioMEMS) technologies. Magnetic microactuators, produced with MEMS technologies, have been operated in biological fluids without the need for a directly wired power supply or control electronics. Such a microactuator technology could be used to mitigate catheter obstruction in a permanently implanted device.
The specific aims are: (1) to design, fabricate, and use an in vitro test setup to analyze the obstruction process, (2) to design and implement a magnetic microactuator can be used to resist obstruction, (3) to use the in vitro setup to analyze the obstruction and the obstruction-clearing1 process for the prototype design.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31NS052044-02
Application #
7095978
Study Section
Special Emphasis Panel (ZRG1-F01 (20))
Program Officer
Pancrazio, Joseph J
Project Start
2005-03-31
Project End
2009-03-30
Budget Start
2006-03-31
Budget End
2007-03-30
Support Year
2
Fiscal Year
2006
Total Cost
$29,209
Indirect Cost
Name
University of California Los Angeles
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Lee, Selene A; Pinney, James R; Khialeeva, Elvira et al. (2008) Functional evaluation of magnetic microactuators for removing biological accumulation: an in vitro study. Conf Proc IEEE Eng Med Biol Soc 2008:947-50