Clinicians have long suspected that individuals with cerebral palsy (CP) have sensory as well as motor deficits. Unfortunately, the literature on sensory deficits in this population inconsistently supports this claim. The proposed study seeks to quantify the somatosensory deficits of patients with CP, and to relate these deficits to activity in the somatosensory cortical regions as measured with functional MRI (fMRI). We have assembled a battery of tests to quantify discriminative touch, vibratory sense, joint proprioception, and stereognosis. We will test these sensory modalities in 20 individuals with diplegia, 20 with hemiplegia, and 20 controls. Detailed analyses of somatosensory cortical activity recorded with a 3T MR scanner will enable correlations between somatosensory cortical activity and somatosensory deficits. Our hypothesis is that sensory deficits are far more prevalent in this population than previously suspected, and that these can be related to abnormal cortical activity. A secondary goal is to relate these aspects to functional motor performance in individuals with CP. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31NS054413-01
Application #
7053634
Study Section
Special Emphasis Panel (ZRG1-F01-R (20))
Program Officer
Chen, Daofen
Project Start
2005-12-02
Project End
2007-12-01
Budget Start
2005-12-02
Budget End
2006-12-01
Support Year
1
Fiscal Year
2006
Total Cost
$28,981
Indirect Cost
Name
Washington University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Wingert, Jason R; Sinclair, Robert J; Dixit, Sachin et al. (2010) Somatosensory-evoked cortical activity in spastic diplegic cerebral palsy. Hum Brain Mapp 31:1772-85
Wingert, Jason R; Burton, Harold; Sinclair, Robert J et al. (2009) Joint-position sense and kinesthesia in cerebral palsy. Arch Phys Med Rehabil 90:447-53
Wingert, Jason R; Burton, Harold; Sinclair, Robert J et al. (2008) Tactile sensory abilities in cerebral palsy: deficits in roughness and object discrimination. Dev Med Child Neurol 50:832-8