Cerebellar damage causes motor coordination deficits or 'ataxia'-movements are variable and inaccurate, despite normal strength. Why cerebellar damage leads to these deficits is not understood. One prominent theory is that the cerebellum calibrates and maintains subconscious internal models, or knowledge of dynamic properties (e.g. inertia, viscosity), of body parts and objects. This project is aimed at testing this theory and determining whether a robotic device can be used to compensate for these deficits.
The first aim will examine whether movement deficits are due to a misestimate of arm dynamic properties in the cerebellum, and whether it can be compensated for. This will be accomplished by comparing arm movements of individuals that have cerebellar damage with movements of control subjects and with simulations using computational models. An exoskeleton robot will then be used to correct for the identified movement impairments.
The second aim will examine whether cerebellar deficits extend beyond movement control to perception of dynamic properties. It is expected that these individuals will not have basic sensory deficits (e.g. limb position sense), but will have difficulty perceiving dynamic properties that rely on both movement and sensory processing. Based on these findings, the robot will be used to test strategies for improving perceptual deficits. The investigator will receive training in neuroscience, neurology, mathematics, and robotics in order to conduct this work. This will be accomplished through didactic work, seminar attendance, and hands on training in the laboratory. This work is important for understanding and developing novel rehabilitation treatments for individuals with cerebellar damage. It is particularly important because there are currently no proven treatments for cerebellar ataxia.

Public Health Relevance

This research will improve understanding of the role of the cerebellum in movement control and perception. It will advance our knowledge of the neural control of arm movements and lead to improvements in rehabilitation for patients with cerebellar damage.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Predoctoral Individual National Research Service Award (F31)
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Special Emphasis Panel (ZRG1-F02B-Y (20))
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Chen, Daofen
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Hugo W. Moser Research Institute Kennedy Krieger
United States
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Bhanpuri, Nasir H; Okamura, Allison M; Bastian, Amy J (2014) Predicting and correcting ataxia using a model of cerebellar function. Brain 137:1931-44
Bhanpuri, Nasir H; Okamura, Allison M; Bastian, Amy J (2013) Predictive modeling by the cerebellum improves proprioception. J Neurosci 33:14301-6
Bhanpuri, Nasir H; Okamura, Allison M; Bastian, Amy J (2012) Active force perception depends on cerebellar function. J Neurophysiol 107:1612-20