The differentiation of oligodendrocytes from progenitors requires a complex sequence of molecular and morphological events. This proposal investigates mechanisms responsible for nuclear size reduction and chromatin condensation that distinguish oligodendrocyte nuclei from other lineages. Besides the conceptual and technological novelty, this proposal is highly relevant for a better understanding of the mechanism of cell identity and for the implications it may have on a large number of pathologies of the central nervous system.

Public Health Relevance

Oligodendrocytes are implicated in numerous psychiatric and neurological disorders, such as schizophrenia, autism, multiple sclerosis and leukodystrophies, where oligodendrocyte differentiation or survival is impaired. Therefore understanding the molecular mechanisms underlying these events will lead to a better understanding of these pathologies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31NS083344-01
Application #
8527254
Study Section
Special Emphasis Panel (ZRG1-F03A-N (20))
Program Officer
Morris, Jill A
Project Start
2013-03-04
Project End
2016-03-03
Budget Start
2013-03-04
Budget End
2014-03-03
Support Year
1
Fiscal Year
2013
Total Cost
$32,990
Indirect Cost
Name
Icahn School of Medicine at Mount Sinai
Department
Neurosciences
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029