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Although most people are capable of limiting alcohol use for recreational purposes, others tend to drink in an excessive and uncontrolled fashion. In addition, these individuals often drink to alleviate aversive conditions associated with alcohol withdrawal (such as anxiety or depression), and are therefore described as being dependent on alcohol.
This research aims to understand the neural mechanisms of alcohol dependence and to facilitate the development of new medications that target excessive drinking in dependent individuals.
|Edwards, Scott; Guerrero, Miguel; Ghoneim, Ola M et al. (2012) Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats. Addict Biol 17:76-85|
|Edwards, Scott; Vendruscolo, Leandro F; Schlosburg, Joel E et al. (2012) Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: alleviation by CRFýýý receptor antagonism. Neuropharmacology 62:1142-51|
|Edwards, Scott; Koob, George F (2012) Experimental psychiatric illness and drug abuse models: from human to animal, an overview. Methods Mol Biol 829:31-48|
|Egli, Mark; Koob, George F; Edwards, Scott (2012) Alcohol dependence as a chronic pain disorder. Neurosci Biobehav Rev 36:2179-92|
|Edwards, Scott; Koob, George F (2010) Neurobiology of dysregulated motivational systems in drug addiction. Future Neurol 5:393-401|