The objective of this independent postdoctoral fellowship award (F32) is to support the candidate's training goals to gain knowledge on substance use and psychiatric outcomes, expertise in genetic epidemiological and gene-finding methods, and further develop the skills needed for an academic research career. To achieve these training goals, the candidate will use genetically informed designs to characterize the associations between externalizing behavior and relationship factors. Numerous studies document associations among externalizing behavior (e.g., alcohol and illicit drug abuse and dependence and antisocial behavior), marital status, and romantic relationship dysfunction. Externalizing behavior and relationship traits are both under genetic influence;still, little is known about their associations from a genetic perspective. Characterizing these associations is important in view of growing evidence that genetic predispositions and environmental risk factors are not independent of one another. With respect to the present project, for example, behavioral disinhibition (i.e., the highly heritable factor shared among externalizing behaviors) also compromises the interpersonal processes (e.g., conflict resolution, trust, and commitment) that are central to the formation and maintenance of harmonious romantic relationships. Two central hypotheses guide this work. First, it is expected that marital status and relationship dysfunction will have a common genetic basis with externalizing behavior. Second, it is expected that, after accounting for gene-environment correlation, marital status and relationship dysfunction will moderate genetic influences on externalizing behavior. The first part of this project will use genetic epidemiological (i.e., twin) methods to examine whether externalizing behavior and romantic relationship factors share latent genetic influences and whether romantic relationship factors moderate latent genetic influences on externalizing behavior. The second part of this project will use gene-finding methods to examine whether externalizing behavior and relationship factors share measured genetic influences, and whether relationship factors moderate measured genetic influences on externalizing behavior. Thus, this work uses complementary genetically-informed methods (twin studies and gene identification methods) to determine the extent to which genetic and/or environmental influences toward externalizing behavior also influence one's propensity to marry, divorce, or have a dysfunctional relationship, and whether relationship factors moderate genetic influences on externalizing behavior. This work contributes to a central goal of psychiatric research, which is to understand how salient environmental factors, such as marital status and relationship dysfunction, come together with genetic predispositions to predict the onset and course of disorders.

Public Health Relevance

The proposed research is relevant to public health because it considers how relationship-related environmental factors in adulthood come together with genetic predispositions to predict socially costly externalizing behaviors (e.g., alcohol and illict drug abuse and dependence and antisocial behavior). The project is relevant to NIH's mission because it aims to provide basic scientific insights into gene- environment correlation and gene-environment interaction processes underlying this important public health problem. The findings may have implications for preventive intervention efforts that focus on bolstering relationship skills as a way to protect individuals at genetic risk for externalizing behavior from close relationship experiences that would worsen their predispositions.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Postdoctoral Individual National Research Service Award (F32)
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Biomedical Research Review Subcommittee (AA)
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Parsian, Abbas
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Virginia Commonwealth University
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Salvatore, Jessica E; Thomas, Nathaniel S; Cho, Seung Bin et al. (2016) The role of romantic relationship status in pathways of risk for emerging adult alcohol use. Psychol Addict Behav 30:335-44
Goyal, Neeru; Aliev, Fazil; Latendresse, Shawn J et al. (2016) Genes involved in stress response and alcohol use among high-risk African American youth. Subst Abus :0
Kendler, Kenneth S; Lönn, Sara Larsson; Salvatore, Jessica et al. (2016) Effect of Marriage on Risk for Onset of Alcohol Use Disorder: A Longitudinal and Co-Relative Analysis in a Swedish National Sample. Am J Psychiatry 173:911-8
Barr, Peter B; Salvatore, Jessica E; Maes, Hermine et al. (2016) Education and alcohol use: A study of gene-environment interaction in young adulthood. Soc Sci Med 162:158-67
Salvatore, Jessica E; Dick, Danielle M (2016) Genetic influences on conduct disorder. Neurosci Biobehav Rev :
Wetherill, Leah; Agrawal, Arpana; Kapoor, Manav et al. (2015) Association of substance dependence phenotypes in the COGA sample. Addict Biol 20:617-27
Salvatore, Jessica E; Gottesman, Irving I; Dick, Danielle M (2015) Endophenotypes for Alcohol Use Disorder: An Update on the Field. Curr Addict Rep 2:76-90
Salvatore, Jessica E; Meyers, Jacquelyn L; Yan, Jia et al. (2015) Intergenerational continuity in parents' and adolescents' externalizing problems: The role of life events and their interaction with GABRA2. J Abnorm Psychol 124:709-28
Salvatore, Jessica E; Aliev, Fazil; Bucholz, Kathleen et al. (2015) Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults. Clin Psychol Sci 3:189-201
Edwards, Alexis C; Aliev, Fazil; Wolen, Aaron R et al. (2015) Genomic influences on alcohol problems in a population-based sample of young adults. Addiction 110:461-70

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